CD11c gene expression in hairy cell leukemia is dependent upon activation of the proto-oncogenes ras and junD

Hairy cell leukemia (HCL) is a chronic lymphoproliferative disease, the cause of which is unknown. Diagnostic of HCL is abnormal expression of the gene that encodes the beta2 integrin CD11c. In order to determine the cause of CD11c gene expression in HCL the CD11c gene promoter was characterized. Tr...

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Veröffentlicht in:	Blood 2003-05, Vol.101 (10), p.4033-4041
Hauptverfasser:	NICOLAOU, Fotini, TEODORIDIS, Jens M, ARNAOUT, M. Amin, SHELLEY, C. Simon, PARK, Heiyoung, GEORGAKIS, Alexander, FAROKHZAD, Omid C, BÖTTINGER, Erwin P, DA SILVA, Nicolas, ROUSSELOT, Philippe, CHOMIENNE, Christine, FERENCZI, Katalin
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD - genetics Base Sequence Binding Sites Biological and medical sciences Butadienes - pharmacology CD11c Antigen - genetics Cell Division - drug effects Enzyme Inhibitors - pharmacology Gene Expression Regulation, Neoplastic Genes, jun Genes, ras HeLa Cells Hematologic and hematopoietic diseases Humans Leukemia, Hairy Cell - genetics Leukemia, Hairy Cell - immunology Leukemia, Hairy Cell - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Molecular Sequence Data Nitriles - pharmacology Plasmids Promoter Regions, Genetic Proto-Oncogenes Transcription Factor AP-1 - metabolism Tumor Cells, Cultured U937 Cells
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