Comparison of 1-Hour and 3-Hours Paclitaxel Infusion Pharmacokinetics: Results from a Randomized Trial

Purpose: Aim of this study was to characterize the difference in pharmacokinetics (PK) of paclitaxel (PAC) after 1-h and 3-h infusion in humans and to define a pharmacodynamic relationship between PAC PK and myelotoxicity. Patients and Methods: PAC PK were studied during the first PAC application in...

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Veröffentlicht in:	Oncology research and treatment 2002-12, Vol.25 (6), p.503-508
Hauptverfasser:	Mross, K., Häring, B., Holländer, N., Mielke, S., Behringer, D., Massing, U., Unger, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - adverse effects Antineoplastic Agents, Phytogenic - pharmacokinetics Chromatography, High Pressure Liquid Drug Administration Schedule Female Focus: Experimental Oncology · Original Article Half-Life Humans Infusions, Intravenous Leukocyte Count Liver Function Tests Male Metabolic Clearance Rate - physiology Middle Aged Neoplasms - blood Neoplasms - drug therapy Neutrophils - drug effects Paclitaxel - administration & dosage Paclitaxel - adverse effects Paclitaxel - pharmacokinetics
Online-Zugang:	Volltext
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