Preclinical and clinical evaluation of four gemcitabine plus carboplatin schedules as front-line treatment for stage IV non-small-cell lung cancer

Background: To explore the activity and tolerability of gemcitabine (GEM) and carboplatin (CBDCA) in non-small-cell lung cancer (NSCLC) we tested four administration sequences on H460 NSCLC cells, and at the same time performed a randomized phase II trial using analogous schedules. Patients and meth...

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Veröffentlicht in:	Annals of oncology 2003-02, Vol.14 (2), p.242-247
Hauptverfasser:	Bajetta, E., Stani, S. C., De Candis, D., Zaffaroni, N., Zilembo, N., Cortinovis, D., Aglione, S., Mariani, L., Formisano, B., Bidoli, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Carboplatin - administration & dosage Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - pathology Chemotherapy Deoxycytidine - administration & dosage Deoxycytidine - analogs & derivatives Drug Administration Schedule Female gemcitabine Humans Infusions, Intravenous Key words: carboplatin Lung Neoplasms - drug therapy Lung Neoplasms - pathology Male Medical sciences Middle Aged Neoplasm Metastasis Neutropenia - chemically induced non-small-cell lung cancer Pharmacology. Drug treatments Survival Thrombocytopenia - chemically induced Treatment Outcome Tumor Cells, Cultured
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