Oral mucosal keratinocytes express RANTES and ICAM-1, but not interleukin-8, in oral lichen planus and oral lichenoid reactions induced by amalgam fillings
Summary Oral lichen planus (OLP) is a chronic inflammatory disease of the oral mucosa characterized by a band‐like accumulation of lymphocytes in the connective tissue adjacent to the basement membrane as well as intraepithelially. Amalgam fillings can induce oral lichenoid reactions (OLR) that are...
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| Veröffentlicht in: | Clinical and experimental dermatology 2003-01, Vol.28 (1), p.64-69 |
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| creator | Little, M. C. Griffiths, C. E. M. Watson, R. E. B. Pemberton, M. N. Thornhill, M. H. |
| description | Summary
Oral lichen planus (OLP) is a chronic inflammatory disease of the oral mucosa characterized by a band‐like accumulation of lymphocytes in the connective tissue adjacent to the basement membrane as well as intraepithelially. Amalgam fillings can induce oral lichenoid reactions (OLR) that are similar to OLP. The adhesion molecule ICAM‐1 and the chemokines interleukin‐8 and RANTES all play central roles in leucocyte trafficking. The aim of this study was to investigate the possible role of these molecules in the migration of leucocytes into the oral mucosa in OLP and OLR. Standard immunoperoxidase techniques were used to visualize the expression of ICAM‐1, RANTES and interleukin‐8 in frozen biopsy sections. ICAM‐1 was expressed by endothelial cells, but not by keratinocytes, in normal oral mucosa. ICAM‐1 was expressed by keratinocytes in 11 of 12 biopsies of OLP and in six of seven biopsies of OLR. In all of these cases ICAM‐1 was also expressed by endothelial cells and leucocytes. Although not present in normal oral mucosa, RANTES was expressed by keratinocytes in 21 of 24 biopsies of OLP and in seven of seven cases of OLR. Interleukin‐8 was not detected in any of the samples. The expression of ICAM‐1 and RANTES by epithelial keratinocytes in the oral mucosa in OLP and OLR could be a key inflammatory mechanism in these diseases. |
| doi_str_mv | 10.1046/j.1365-2230.2003.01158.x |
| format | Article |
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Oral lichen planus (OLP) is a chronic inflammatory disease of the oral mucosa characterized by a band‐like accumulation of lymphocytes in the connective tissue adjacent to the basement membrane as well as intraepithelially. Amalgam fillings can induce oral lichenoid reactions (OLR) that are similar to OLP. The adhesion molecule ICAM‐1 and the chemokines interleukin‐8 and RANTES all play central roles in leucocyte trafficking. The aim of this study was to investigate the possible role of these molecules in the migration of leucocytes into the oral mucosa in OLP and OLR. Standard immunoperoxidase techniques were used to visualize the expression of ICAM‐1, RANTES and interleukin‐8 in frozen biopsy sections. ICAM‐1 was expressed by endothelial cells, but not by keratinocytes, in normal oral mucosa. ICAM‐1 was expressed by keratinocytes in 11 of 12 biopsies of OLP and in six of seven biopsies of OLR. In all of these cases ICAM‐1 was also expressed by endothelial cells and leucocytes. Although not present in normal oral mucosa, RANTES was expressed by keratinocytes in 21 of 24 biopsies of OLP and in seven of seven cases of OLR. Interleukin‐8 was not detected in any of the samples. The expression of ICAM‐1 and RANTES by epithelial keratinocytes in the oral mucosa in OLP and OLR could be a key inflammatory mechanism in these diseases.</description><identifier>ISSN: 0307-6938</identifier><identifier>EISSN: 1365-2230</identifier><identifier>DOI: 10.1046/j.1365-2230.2003.01158.x</identifier><identifier>PMID: 12558634</identifier><identifier>CODEN: CEDEDE</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Adult ; Aged ; Antibodies, Monoclonal - analysis ; Biological and medical sciences ; Biopsy - methods ; Chemokine CCL5 - analysis ; Dental Amalgam - adverse effects ; Dermatology ; Female ; Humans ; Immunohistochemistry - methods ; Intercellular Adhesion Molecule-1 - analysis ; Interleukin-8 - analysis ; Keratinocytes - chemistry ; Lichen Planus, Oral - chemically induced ; Lichen Planus, Oral - metabolism ; Lichen Planus, Oral - pathology ; Male ; Medical sciences ; Middle Aged ; Mouth Mucosa - chemistry ; Mouth Mucosa - pathology ; Psoriasis. Parapsoriasis. Lichen ; Skin involvement in other diseases. Miscellaneous. General aspects</subject><ispartof>Clinical and experimental dermatology, 2003-01, Vol.28 (1), p.64-69</ispartof><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3848-3672fc9da067133d716b5be8c7300f94b5237e82d00a692e2afc9d5cc77b8e8e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4023,27922,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14648226$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12558634$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Little, M. C.</creatorcontrib><creatorcontrib>Griffiths, C. E. M.</creatorcontrib><creatorcontrib>Watson, R. E. B.</creatorcontrib><creatorcontrib>Pemberton, M. N.</creatorcontrib><creatorcontrib>Thornhill, M. H.</creatorcontrib><title>Oral mucosal keratinocytes express RANTES and ICAM-1, but not interleukin-8, in oral lichen planus and oral lichenoid reactions induced by amalgam fillings</title><title>Clinical and experimental dermatology</title><addtitle>Clin Exp Dermatol</addtitle><description>Summary
Oral lichen planus (OLP) is a chronic inflammatory disease of the oral mucosa characterized by a band‐like accumulation of lymphocytes in the connective tissue adjacent to the basement membrane as well as intraepithelially. Amalgam fillings can induce oral lichenoid reactions (OLR) that are similar to OLP. The adhesion molecule ICAM‐1 and the chemokines interleukin‐8 and RANTES all play central roles in leucocyte trafficking. The aim of this study was to investigate the possible role of these molecules in the migration of leucocytes into the oral mucosa in OLP and OLR. Standard immunoperoxidase techniques were used to visualize the expression of ICAM‐1, RANTES and interleukin‐8 in frozen biopsy sections. ICAM‐1 was expressed by endothelial cells, but not by keratinocytes, in normal oral mucosa. ICAM‐1 was expressed by keratinocytes in 11 of 12 biopsies of OLP and in six of seven biopsies of OLR. In all of these cases ICAM‐1 was also expressed by endothelial cells and leucocytes. Although not present in normal oral mucosa, RANTES was expressed by keratinocytes in 21 of 24 biopsies of OLP and in seven of seven cases of OLR. Interleukin‐8 was not detected in any of the samples. The expression of ICAM‐1 and RANTES by epithelial keratinocytes in the oral mucosa in OLP and OLR could be a key inflammatory mechanism in these diseases.</description><subject>Adult</subject><subject>Aged</subject><subject>Antibodies, Monoclonal - analysis</subject><subject>Biological and medical sciences</subject><subject>Biopsy - methods</subject><subject>Chemokine CCL5 - analysis</subject><subject>Dental Amalgam - adverse effects</subject><subject>Dermatology</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry - methods</subject><subject>Intercellular Adhesion Molecule-1 - analysis</subject><subject>Interleukin-8 - analysis</subject><subject>Keratinocytes - chemistry</subject><subject>Lichen Planus, Oral - chemically induced</subject><subject>Lichen Planus, Oral - metabolism</subject><subject>Lichen Planus, Oral - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mouth Mucosa - chemistry</subject><subject>Mouth Mucosa - pathology</subject><subject>Psoriasis. Parapsoriasis. Lichen</subject><subject>Skin involvement in other diseases. Miscellaneous. General aspects</subject><issn>0307-6938</issn><issn>1365-2230</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkctu1DAUhi0EotPCKyBv2DWpL_FlFixKGKZIpZVguIiN5ThO8YzjjOxEnXmWvmyTTmlZHdvn-46O_AMAMcoxKvjZOseUs4wQinKCEM0Rxkzmuxdg9tR4CWaIIpHxOZVH4DilNUKYYsFegyNMGJOcFjNwdx21h-1gujTWjY26d6Ez-94maHfbaFOC386vVovvUIcafinPv2b4FFZDD0PXQxd6G70dNi5k8nS8wm6a5535awPceh2G9CD-99y5GkarTe-6kEalHoytYbWHutX-Rrewcd67cJPegFeN9sm-fawn4Mfnxaq8yC6vl-Mil5mhspAZ5YI0Zl5rxAWmtBaYV6yy0giKUDMvKkaosJLUCGk-J5boiWbGCFFJKy09Ae8Oc7dD1dpabaNrddyrf780Au8fAZ2M9k3Uwbj0zBW8kITwkftw4G6dt_vnPlJTamqtpnDUFI6aUlMPqamdKhefptPoZwffpd7unnwdN4oLKpj6dbVU5ernb7n8-EeV9B44CprJ</recordid><startdate>200301</startdate><enddate>200301</enddate><creator>Little, M. C.</creator><creator>Griffiths, C. E. M.</creator><creator>Watson, R. E. B.</creator><creator>Pemberton, M. N.</creator><creator>Thornhill, M. H.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>200301</creationdate><title>Oral mucosal keratinocytes express RANTES and ICAM-1, but not interleukin-8, in oral lichen planus and oral lichenoid reactions induced by amalgam fillings</title><author>Little, M. C. ; Griffiths, C. E. M. ; Watson, R. E. B. ; Pemberton, M. N. ; Thornhill, M. H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3848-3672fc9da067133d716b5be8c7300f94b5237e82d00a692e2afc9d5cc77b8e8e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antibodies, Monoclonal - analysis</topic><topic>Biological and medical sciences</topic><topic>Biopsy - methods</topic><topic>Chemokine CCL5 - analysis</topic><topic>Dental Amalgam - adverse effects</topic><topic>Dermatology</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry - methods</topic><topic>Intercellular Adhesion Molecule-1 - analysis</topic><topic>Interleukin-8 - analysis</topic><topic>Keratinocytes - chemistry</topic><topic>Lichen Planus, Oral - chemically induced</topic><topic>Lichen Planus, Oral - metabolism</topic><topic>Lichen Planus, Oral - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mouth Mucosa - chemistry</topic><topic>Mouth Mucosa - pathology</topic><topic>Psoriasis. Parapsoriasis. Lichen</topic><topic>Skin involvement in other diseases. Miscellaneous. General aspects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Little, M. C.</creatorcontrib><creatorcontrib>Griffiths, C. E. M.</creatorcontrib><creatorcontrib>Watson, R. E. B.</creatorcontrib><creatorcontrib>Pemberton, M. N.</creatorcontrib><creatorcontrib>Thornhill, M. H.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Clinical and experimental dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Little, M. C.</au><au>Griffiths, C. E. M.</au><au>Watson, R. E. B.</au><au>Pemberton, M. N.</au><au>Thornhill, M. H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oral mucosal keratinocytes express RANTES and ICAM-1, but not interleukin-8, in oral lichen planus and oral lichenoid reactions induced by amalgam fillings</atitle><jtitle>Clinical and experimental dermatology</jtitle><addtitle>Clin Exp Dermatol</addtitle><date>2003-01</date><risdate>2003</risdate><volume>28</volume><issue>1</issue><spage>64</spage><epage>69</epage><pages>64-69</pages><issn>0307-6938</issn><eissn>1365-2230</eissn><coden>CEDEDE</coden><abstract>Summary
Oral lichen planus (OLP) is a chronic inflammatory disease of the oral mucosa characterized by a band‐like accumulation of lymphocytes in the connective tissue adjacent to the basement membrane as well as intraepithelially. Amalgam fillings can induce oral lichenoid reactions (OLR) that are similar to OLP. The adhesion molecule ICAM‐1 and the chemokines interleukin‐8 and RANTES all play central roles in leucocyte trafficking. The aim of this study was to investigate the possible role of these molecules in the migration of leucocytes into the oral mucosa in OLP and OLR. Standard immunoperoxidase techniques were used to visualize the expression of ICAM‐1, RANTES and interleukin‐8 in frozen biopsy sections. ICAM‐1 was expressed by endothelial cells, but not by keratinocytes, in normal oral mucosa. ICAM‐1 was expressed by keratinocytes in 11 of 12 biopsies of OLP and in six of seven biopsies of OLR. In all of these cases ICAM‐1 was also expressed by endothelial cells and leucocytes. Although not present in normal oral mucosa, RANTES was expressed by keratinocytes in 21 of 24 biopsies of OLP and in seven of seven cases of OLR. Interleukin‐8 was not detected in any of the samples. The expression of ICAM‐1 and RANTES by epithelial keratinocytes in the oral mucosa in OLP and OLR could be a key inflammatory mechanism in these diseases.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>12558634</pmid><doi>10.1046/j.1365-2230.2003.01158.x</doi><tpages>6</tpages></addata></record> |
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| ispartof | Clinical and experimental dermatology, 2003-01, Vol.28 (1), p.64-69 |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Adult Aged Antibodies, Monoclonal - analysis Biological and medical sciences Biopsy - methods Chemokine CCL5 - analysis Dental Amalgam - adverse effects Dermatology Female Humans Immunohistochemistry - methods Intercellular Adhesion Molecule-1 - analysis Interleukin-8 - analysis Keratinocytes - chemistry Lichen Planus, Oral - chemically induced Lichen Planus, Oral - metabolism Lichen Planus, Oral - pathology Male Medical sciences Middle Aged Mouth Mucosa - chemistry Mouth Mucosa - pathology Psoriasis. Parapsoriasis. Lichen Skin involvement in other diseases. Miscellaneous. General aspects |
| title | Oral mucosal keratinocytes express RANTES and ICAM-1, but not interleukin-8, in oral lichen planus and oral lichenoid reactions induced by amalgam fillings |
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