Mechanism of molecular interactions for tRNA(Val) recognition by valyl-tRNA synthetase

The molecular interactions between valyl-tRNA synthetase (ValRS) and tRNA(Val), with the C34-A35-C36 anticodon, from Thermus thermophilus were studied by crystallographic analysis and structure-based mutagenesis. In the ValRS-bound structure of tRNA(Val), the successive A35-C36 residues (the major i...

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Veröffentlicht in:	RNA (Cambridge) 2003-01, Vol.9 (1), p.100
Hauptverfasser:	Fukai, Shuya, Nureki, Osamu, Sekine, Shun-Ichi, Shimada, Atsushi, Vassylyev, Dmitry G, Yokoyama, Shigeyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticodon Hydrogen Bonding Kinetics Models, Molecular Protein Conformation RNA, Transfer, Val - metabolism Thermus thermophilus - enzymology Valine-tRNA Ligase - chemistry Valine-tRNA Ligase - metabolism
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