Heat shock protein 70: role in antigen presentation and immune stimulation

Heat shock proteins (HSP) when released into the extracellular milieu can act simultaneously as a source of antigen due to their ability to chaperone peptides and as a maturation signal for dendritic cells, thereby inducing DCs to cross-present antigens to CD8+ T-cells. HSP can also act independentl...

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Veröffentlicht in:	International journal of hyperthermia 2002-11, Vol.18 (6), p.563-575
Hauptverfasser:	Milani, V., Noessner, E., Ghose, S., Kuppner, M., Ahrens, B., Scharner, A., Gastpar, R., Issels, R. D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen Presentation Antigen Presentation - physiology Dendritic Cells HSP70 Heat-Shock Proteins - immunology Human Model Humans Hyperthermia Immune System - physiology Toll-LIKE Receptor Tumour Immunity
Online-Zugang:	Volltext
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