Routes to S-Nitroso-Hemoglobin Formation with Heme Redox and Preferential Reactivity in the β Subunits

Previous studies of the interactions of NO with human hemoglobin have implied the predominance of reaction channels that alternatively eliminate NO by converting it to nitrate, or tightly complex it on the α subunit ferrous hemes. Both channels could effectively quench NO bioactivity. More recent wo...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2003-01, Vol.100 (2), p.461-466
Hauptverfasser:	Luchsinger, Benjamin P., Rich, Eric N., Gow, Andrew J., Williams, Elizabeth M., Stamler, Jonathan S., Singel, David J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biological Sciences Blood chemistry Chemical reactions Heme - chemistry Heme - metabolism Hemoglobins Hemoglobins - biosynthesis Hems Humans Kinetics Nitric oxide Nitric Oxide - metabolism Nitrites Nitrosyls Oxidation Oxidation-Reduction Protein Subunits Spectroscopic analysis Thiols
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