Estrogen modulation of baroreflex function in conscious mice
1 Dalton Cardiovascular Research Center, 2 Department of Veterinary Biomedical Sciences, 3 Department of Biochemistry and Child Health, 4 Center for Phytonutrient and Phytochemical Studies, University of Missouri, Columbia, Missouri 65211 It has been suggested that estrogen modulates baroreflex...
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| Veröffentlicht in: | American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2003-04, Vol.284 (4), p.983-R989 |
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| container_title | American journal of physiology. Regulatory, integrative and comparative physiology |
| container_volume | 284 |
| creator | Pamidimukkala, Jaya Taylor, Julia A Welshons, Wade V Lubahn, Dennis B Hay, Meredith |
| description | 1 Dalton Cardiovascular Research Center, 2 Department
of Veterinary Biomedical Sciences, 3 Department of
Biochemistry and Child Health, 4 Center for Phytonutrient
and Phytochemical Studies, University of Missouri, Columbia,
Missouri 65211
It
has been suggested that estrogen modulates baroreflex regulation of
autonomic function. The present study evaluated the effects of estrogen
on baroreflex regulation of heart rate in response to changes in blood
pressure with phenylephrine (PE), ANG II, and sodium nitroprusside
(SNP) in a conscious mouse model. Males and ovariectomized females with
(OvxE+) and without (OvxE ) estradiol replacement chronically
implanted with arterial and venous catheters were used in these
studies. The slope of the baroreflex bradycardic responses to PE was
significantly facilitated in OvxE+ females ( 7.65 ± 1.37)
compared with OvxE females ( 4.5 ± 0.4). Likewise, the slope
of the baroreflex bradycardic responses to ANG II was significantly
facilitated in OvxE+ females ( 7.97 ± 1.06) compared with OvxE
females ( 4.8 ± 1.6). Reflex tachycardic responses to SNP were
comparable in all the groups. Finally, in male mice, the slope of ANG
II-induced baroreflex bradycardia ( 5.17 ± 0.95) was
significantly less than that induced by PE ( 8.50 ± 0.92), but
this ANG II-mediated attenuation of reflex bradycardia was not observed
in the female mice. These data support the hypothesis that estrogen
facilitates baroreflex function in female mice and suggest that ANG
II-mediated acute blunting of baroreflex regulation of heart rate may
be sex dependent.
gender differences; autonomic regulation; cardiac baroreflexes |
| doi_str_mv | 10.1152/ajpregu.00761.2001 |
| format | Article |
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of Veterinary Biomedical Sciences, 3 Department of
Biochemistry and Child Health, 4 Center for Phytonutrient
and Phytochemical Studies, University of Missouri, Columbia,
Missouri 65211
It
has been suggested that estrogen modulates baroreflex regulation of
autonomic function. The present study evaluated the effects of estrogen
on baroreflex regulation of heart rate in response to changes in blood
pressure with phenylephrine (PE), ANG II, and sodium nitroprusside
(SNP) in a conscious mouse model. Males and ovariectomized females with
(OvxE+) and without (OvxE ) estradiol replacement chronically
implanted with arterial and venous catheters were used in these
studies. The slope of the baroreflex bradycardic responses to PE was
significantly facilitated in OvxE+ females ( 7.65 ± 1.37)
compared with OvxE females ( 4.5 ± 0.4). Likewise, the slope
of the baroreflex bradycardic responses to ANG II was significantly
facilitated in OvxE+ females ( 7.97 ± 1.06) compared with OvxE
females ( 4.8 ± 1.6). Reflex tachycardic responses to SNP were
comparable in all the groups. Finally, in male mice, the slope of ANG
II-induced baroreflex bradycardia ( 5.17 ± 0.95) was
significantly less than that induced by PE ( 8.50 ± 0.92), but
this ANG II-mediated attenuation of reflex bradycardia was not observed
in the female mice. These data support the hypothesis that estrogen
facilitates baroreflex function in female mice and suggest that ANG
II-mediated acute blunting of baroreflex regulation of heart rate may
be sex dependent.
gender differences; autonomic regulation; cardiac baroreflexes</description><identifier>ISSN: 0363-6119</identifier><identifier>EISSN: 1522-1490</identifier><identifier>DOI: 10.1152/ajpregu.00761.2001</identifier><identifier>PMID: 12521927</identifier><language>eng</language><publisher>United States</publisher><subject>Angiotensin II - pharmacology ; Animals ; Baroreflex - drug effects ; Baroreflex - physiology ; Blood Pressure - drug effects ; Consciousness ; Estrogens - pharmacology ; Female ; Heart Rate - drug effects ; Logistic Models ; Male ; Mice ; Mice, Inbred C57BL ; Nitroprusside - pharmacology ; Ovariectomy ; Phenylephrine - pharmacology ; Sex Factors</subject><ispartof>American journal of physiology. Regulatory, integrative and comparative physiology, 2003-04, Vol.284 (4), p.983-R989</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-daa730c1d09ef2f5d8c6db832088e23f9d45fad942825d80a64934eec26027d23</citedby><cites>FETCH-LOGICAL-c431t-daa730c1d09ef2f5d8c6db832088e23f9d45fad942825d80a64934eec26027d23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3039,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12521927$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pamidimukkala, Jaya</creatorcontrib><creatorcontrib>Taylor, Julia A</creatorcontrib><creatorcontrib>Welshons, Wade V</creatorcontrib><creatorcontrib>Lubahn, Dennis B</creatorcontrib><creatorcontrib>Hay, Meredith</creatorcontrib><title>Estrogen modulation of baroreflex function in conscious mice</title><title>American journal of physiology. Regulatory, integrative and comparative physiology</title><addtitle>Am J Physiol Regul Integr Comp Physiol</addtitle><description>1 Dalton Cardiovascular Research Center, 2 Department
of Veterinary Biomedical Sciences, 3 Department of
Biochemistry and Child Health, 4 Center for Phytonutrient
and Phytochemical Studies, University of Missouri, Columbia,
Missouri 65211
It
has been suggested that estrogen modulates baroreflex regulation of
autonomic function. The present study evaluated the effects of estrogen
on baroreflex regulation of heart rate in response to changes in blood
pressure with phenylephrine (PE), ANG II, and sodium nitroprusside
(SNP) in a conscious mouse model. Males and ovariectomized females with
(OvxE+) and without (OvxE ) estradiol replacement chronically
implanted with arterial and venous catheters were used in these
studies. The slope of the baroreflex bradycardic responses to PE was
significantly facilitated in OvxE+ females ( 7.65 ± 1.37)
compared with OvxE females ( 4.5 ± 0.4). Likewise, the slope
of the baroreflex bradycardic responses to ANG II was significantly
facilitated in OvxE+ females ( 7.97 ± 1.06) compared with OvxE
females ( 4.8 ± 1.6). Reflex tachycardic responses to SNP were
comparable in all the groups. Finally, in male mice, the slope of ANG
II-induced baroreflex bradycardia ( 5.17 ± 0.95) was
significantly less than that induced by PE ( 8.50 ± 0.92), but
this ANG II-mediated attenuation of reflex bradycardia was not observed
in the female mice. These data support the hypothesis that estrogen
facilitates baroreflex function in female mice and suggest that ANG
II-mediated acute blunting of baroreflex regulation of heart rate may
be sex dependent.
gender differences; autonomic regulation; cardiac baroreflexes</description><subject>Angiotensin II - pharmacology</subject><subject>Animals</subject><subject>Baroreflex - drug effects</subject><subject>Baroreflex - physiology</subject><subject>Blood Pressure - drug effects</subject><subject>Consciousness</subject><subject>Estrogens - pharmacology</subject><subject>Female</subject><subject>Heart Rate - drug effects</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Nitroprusside - pharmacology</subject><subject>Ovariectomy</subject><subject>Phenylephrine - pharmacology</subject><subject>Sex Factors</subject><issn>0363-6119</issn><issn>1522-1490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1LwzAchoMobk7_AQ_Sk7fOfPUj4EXGpoIgyDyHLB9dRtvUpMXtv7fbqjt5CuT3vC8vDwC3CE4RSvCD2DReF90UwixFUwwhOgPj_oBjRBk8B2NIUhKnCLERuAphAyGkhJJLMEI4wYjhbAwe56H1rtB1VDnVlaK1ro6ciVbCO69NqbeR6Wp5-LZ1JF0dpHVdiCor9TW4MKIM-mZ4J-BzMV_OXuK39-fX2dNbLClBbayEyAiUSEGmDTaJymWqVjnBMM81JoYpmhihGMU57o9QpJQRqrXEKcSZwmQC7o-9jXdfnQ4tr2yQuixFrfstvG_PSYZID-IjKL0Lod_PG28r4XccQb53xgdn_OCM7531obuhvVtVWp0ig6QeiI_A2hbrb-s1b9a7YF3pit1fIc4pp_yD5fsV7H9-0ZXlUm_b3-ApxxtlyA8AAI7N</recordid><startdate>20030401</startdate><enddate>20030401</enddate><creator>Pamidimukkala, Jaya</creator><creator>Taylor, Julia A</creator><creator>Welshons, Wade V</creator><creator>Lubahn, Dennis B</creator><creator>Hay, Meredith</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030401</creationdate><title>Estrogen modulation of baroreflex function in conscious mice</title><author>Pamidimukkala, Jaya ; Taylor, Julia A ; Welshons, Wade V ; Lubahn, Dennis B ; Hay, Meredith</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-daa730c1d09ef2f5d8c6db832088e23f9d45fad942825d80a64934eec26027d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Angiotensin II - pharmacology</topic><topic>Animals</topic><topic>Baroreflex - drug effects</topic><topic>Baroreflex - physiology</topic><topic>Blood Pressure - drug effects</topic><topic>Consciousness</topic><topic>Estrogens - pharmacology</topic><topic>Female</topic><topic>Heart Rate - drug effects</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Nitroprusside - pharmacology</topic><topic>Ovariectomy</topic><topic>Phenylephrine - pharmacology</topic><topic>Sex Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pamidimukkala, Jaya</creatorcontrib><creatorcontrib>Taylor, Julia A</creatorcontrib><creatorcontrib>Welshons, Wade V</creatorcontrib><creatorcontrib>Lubahn, Dennis B</creatorcontrib><creatorcontrib>Hay, Meredith</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology. Regulatory, integrative and comparative physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pamidimukkala, Jaya</au><au>Taylor, Julia A</au><au>Welshons, Wade V</au><au>Lubahn, Dennis B</au><au>Hay, Meredith</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Estrogen modulation of baroreflex function in conscious mice</atitle><jtitle>American journal of physiology. Regulatory, integrative and comparative physiology</jtitle><addtitle>Am J Physiol Regul Integr Comp Physiol</addtitle><date>2003-04-01</date><risdate>2003</risdate><volume>284</volume><issue>4</issue><spage>983</spage><epage>R989</epage><pages>983-R989</pages><issn>0363-6119</issn><eissn>1522-1490</eissn><abstract>1 Dalton Cardiovascular Research Center, 2 Department
of Veterinary Biomedical Sciences, 3 Department of
Biochemistry and Child Health, 4 Center for Phytonutrient
and Phytochemical Studies, University of Missouri, Columbia,
Missouri 65211
It
has been suggested that estrogen modulates baroreflex regulation of
autonomic function. The present study evaluated the effects of estrogen
on baroreflex regulation of heart rate in response to changes in blood
pressure with phenylephrine (PE), ANG II, and sodium nitroprusside
(SNP) in a conscious mouse model. Males and ovariectomized females with
(OvxE+) and without (OvxE ) estradiol replacement chronically
implanted with arterial and venous catheters were used in these
studies. The slope of the baroreflex bradycardic responses to PE was
significantly facilitated in OvxE+ females ( 7.65 ± 1.37)
compared with OvxE females ( 4.5 ± 0.4). Likewise, the slope
of the baroreflex bradycardic responses to ANG II was significantly
facilitated in OvxE+ females ( 7.97 ± 1.06) compared with OvxE
females ( 4.8 ± 1.6). Reflex tachycardic responses to SNP were
comparable in all the groups. Finally, in male mice, the slope of ANG
II-induced baroreflex bradycardia ( 5.17 ± 0.95) was
significantly less than that induced by PE ( 8.50 ± 0.92), but
this ANG II-mediated attenuation of reflex bradycardia was not observed
in the female mice. These data support the hypothesis that estrogen
facilitates baroreflex function in female mice and suggest that ANG
II-mediated acute blunting of baroreflex regulation of heart rate may
be sex dependent.
gender differences; autonomic regulation; cardiac baroreflexes</abstract><cop>United States</cop><pmid>12521927</pmid><doi>10.1152/ajpregu.00761.2001</doi><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0363-6119 |
| ispartof | American journal of physiology. Regulatory, integrative and comparative physiology, 2003-04, Vol.284 (4), p.983-R989 |
| issn | 0363-6119 1522-1490 |
| language | eng |
| recordid | cdi_pubmed_primary_12521927 |
| source | MEDLINE; American Physiological Society; EZB-FREE-00999 freely available EZB journals |
| subjects | Angiotensin II - pharmacology Animals Baroreflex - drug effects Baroreflex - physiology Blood Pressure - drug effects Consciousness Estrogens - pharmacology Female Heart Rate - drug effects Logistic Models Male Mice Mice, Inbred C57BL Nitroprusside - pharmacology Ovariectomy Phenylephrine - pharmacology Sex Factors |
| title | Estrogen modulation of baroreflex function in conscious mice |
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