A (6-4) Photolyase Model: Repair of DNA (6-4) Lesions Requires a Reduced and Deprotonated Flavin

Photolyase‐catalyzed repair of pyrimidine (6‐4) photoadducts was modeled with synthetic, covalently linked flavin–oxetane 1. The repair reaction (oxetane splitting) requires the reduced flavin in its deprotonated form. The key step of the repair reaction involves an electron transfer from the flavin...

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Veröffentlicht in:	Angewandte Chemie International Edition 2002-03, Vol.41 (5), p.767-770
Hauptverfasser:	Cichon, Michaela K., Arnold, Simone, Carell, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	bioorganic chemistry Chromatography, High Pressure Liquid Deoxyribodipyrimidine Photo-Lyase - metabolism Deoxyribodipyrimidine Photo-Lyase - physiology DNA DNA Repair Ethers, Cyclic - chemistry Ethers, Cyclic - radiation effects Flavins - physiology Models, Chemical mutagenesis Oxidation-Reduction photolyase Pyrimidine Dimers - metabolism
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