Critical review and evaluation of the uterotrophic bioassay for the identification of possible estrogen agonists and antagonists: in support of the validation of the OECD uterotrophic protocols for the laboratory rodent. Organisation for Economic Co-operation and Development

A current issue for regulatory agencies is endocrine-related modes of action such as those mediated by the estrogen, androgen, and thyroid nuclear receptors. At the national and international levels, the consensus recommendation for the assessment of such modes of action is a tiered series of in vit...

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Veröffentlicht in:	Critical reviews in toxicology 2002, Vol.32 (6), p.445
Hauptverfasser:	Owens, J William, Ashby, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Assay - standards Estradiol - toxicity Estrogen Antagonists - toxicity Ethinyl Estradiol - toxicity Female Mice Organ Size Program Evaluation Rats Receptors, Estrogen - agonists Receptors, Estrogen - antagonists & inhibitors Uterus - drug effects Uterus - metabolism Uterus - pathology
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