Combined liver and pancreas resection with biochemotherapy for metastatic ocular melanoma
Systemic therapy alone for metastatic melanoma is relatively ineffective, and surgical resection of metastases to a solitary site remains the best single treatment to improve survival. While cytoreductive surgery plus chemotherapy play a significant role in the management of advanced ovarian cancer,...
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Veröffentlicht in: | Journal of Hepato‐Biliary‐Pancreatic Surgery 2002, Vol.9 (4), p.519-521 |
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container_title | Journal of Hepato‐Biliary‐Pancreatic Surgery |
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creator | Camp, Ramsey Lind, D. Scott Hemming, Alan W. |
description | Systemic therapy alone for metastatic melanoma is relatively ineffective, and surgical resection of metastases to a solitary site remains the best single treatment to improve survival. While cytoreductive surgery plus chemotherapy play a significant role in the management of advanced ovarian cancer, the precise role of surgery as an adjunct to systemic therapy for melanoma metastatic to multiple sites is not well defined. We report a patient with ocular melanoma metastatic to liver and pancreas treated by cytoreductive surgery consisting of mesohepatic resection, distal pancreatectomy, and portal node dissection, followed by biochemotherapy with dacarbazine and interferon alpha. The concept of cytoreductive surgery is reviewed, with particular attention to its use in the management of metastatic melanoma. The patient's postoperative course was unremarkable and she remains alive and asymptomatic with no detectable disease at 20 months' follow‐up. Cytoreductive surgery as a part of an aggressive multidisciplinary approach may play a role in the treatment of cutaneous and ocular melanoma metastatic to multiple visceral sites. Data from well‐designed, innovative clinical trials of cytoreductive surgery and biochemotherapy are required to determine the effectiveness of this multidisciplinary approach. |
doi_str_mv | 10.1007/s005340200066 |
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Scott ; Hemming, Alan W.</creator><creatorcontrib>Camp, Ramsey ; Lind, D. Scott ; Hemming, Alan W.</creatorcontrib><description>Systemic therapy alone for metastatic melanoma is relatively ineffective, and surgical resection of metastases to a solitary site remains the best single treatment to improve survival. While cytoreductive surgery plus chemotherapy play a significant role in the management of advanced ovarian cancer, the precise role of surgery as an adjunct to systemic therapy for melanoma metastatic to multiple sites is not well defined. We report a patient with ocular melanoma metastatic to liver and pancreas treated by cytoreductive surgery consisting of mesohepatic resection, distal pancreatectomy, and portal node dissection, followed by biochemotherapy with dacarbazine and interferon alpha. The concept of cytoreductive surgery is reviewed, with particular attention to its use in the management of metastatic melanoma. The patient's postoperative course was unremarkable and she remains alive and asymptomatic with no detectable disease at 20 months' follow‐up. Cytoreductive surgery as a part of an aggressive multidisciplinary approach may play a role in the treatment of cutaneous and ocular melanoma metastatic to multiple visceral sites. 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Scott</creatorcontrib><creatorcontrib>Hemming, Alan W.</creatorcontrib><title>Combined liver and pancreas resection with biochemotherapy for metastatic ocular melanoma</title><title>Journal of Hepato‐Biliary‐Pancreatic Surgery</title><addtitle>J Hepatobiliary Pancreat Surg</addtitle><description>Systemic therapy alone for metastatic melanoma is relatively ineffective, and surgical resection of metastases to a solitary site remains the best single treatment to improve survival. While cytoreductive surgery plus chemotherapy play a significant role in the management of advanced ovarian cancer, the precise role of surgery as an adjunct to systemic therapy for melanoma metastatic to multiple sites is not well defined. We report a patient with ocular melanoma metastatic to liver and pancreas treated by cytoreductive surgery consisting of mesohepatic resection, distal pancreatectomy, and portal node dissection, followed by biochemotherapy with dacarbazine and interferon alpha. The concept of cytoreductive surgery is reviewed, with particular attention to its use in the management of metastatic melanoma. The patient's postoperative course was unremarkable and she remains alive and asymptomatic with no detectable disease at 20 months' follow‐up. Cytoreductive surgery as a part of an aggressive multidisciplinary approach may play a role in the treatment of cutaneous and ocular melanoma metastatic to multiple visceral sites. Data from well‐designed, innovative clinical trials of cytoreductive surgery and biochemotherapy are required to determine the effectiveness of this multidisciplinary approach.</description><subject>Antineoplastic Agents, Alkylating - therapeutic use</subject><subject>biochemotherapy</subject><subject>cytoreductive surgery</subject><subject>Dacarbazine - therapeutic use</subject><subject>Eye Enucleation</subject><subject>Female</subject><subject>Hepatectomy</subject><subject>Humans</subject><subject>Interferon-alpha - therapeutic use</subject><subject>Liver Neoplasms - secondary</subject><subject>Liver Neoplasms - surgery</subject><subject>Lymph Node Excision</subject><subject>Lymphatic Metastasis</subject><subject>Melanoma - drug therapy</subject><subject>Melanoma - pathology</subject><subject>Melanoma - surgery</subject><subject>Middle Aged</subject><subject>ocular melanoma</subject><subject>Pancreatectomy</subject><subject>Pancreatic Neoplasms - immunology</subject><subject>Pancreatic Neoplasms - surgery</subject><subject>Uveal Neoplasms - drug therapy</subject><subject>Uveal Neoplasms - pathology</subject><subject>Uveal Neoplasms - surgery</subject><issn>0944-1166</issn><issn>1868-6982</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE1LAzEYhIMotlaPXiV_YPVNNl971KJWKehBD56WJH1DI7ubJbu19N9rURFPAzMPAzOEnDO4ZAD6agCQpQAOAEodkCkzyhSqMvyQTKESomBMqQk5GYZ3AKal0cdkwrgwJdd6St7mqXWxwxVt4gdmarsV7W3nM9qBZhzQjzF1dBvHNXUx-TW2aVxjtv2OhpRpi6MdRjtGT5PfNHbvNLZLrT0lR8E2A5796Iy83t2-zBfF8un-YX69LDxXXBfGW61CMLaSoWSV8UKihCCQo9NBVq4SzgdttAAjjdHcVSWTzkupHQIvyxm5-O7tN67FVd3n2Nq8q383fgH8G9jGBnd_OdT7A-t_B9aPi5tnI3T5CWB_Yvw</recordid><startdate>2002</startdate><enddate>2002</enddate><creator>Camp, Ramsey</creator><creator>Lind, D. 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Scott ; Hemming, Alan W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2627-8ca76ff8a95f3198c45e50f4e2eb7f59b94bcf78740858872b9315bc557be0233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Antineoplastic Agents, Alkylating - therapeutic use</topic><topic>biochemotherapy</topic><topic>cytoreductive surgery</topic><topic>Dacarbazine - therapeutic use</topic><topic>Eye Enucleation</topic><topic>Female</topic><topic>Hepatectomy</topic><topic>Humans</topic><topic>Interferon-alpha - therapeutic use</topic><topic>Liver Neoplasms - secondary</topic><topic>Liver Neoplasms - surgery</topic><topic>Lymph Node Excision</topic><topic>Lymphatic Metastasis</topic><topic>Melanoma - drug therapy</topic><topic>Melanoma - pathology</topic><topic>Melanoma - surgery</topic><topic>Middle Aged</topic><topic>ocular melanoma</topic><topic>Pancreatectomy</topic><topic>Pancreatic Neoplasms - immunology</topic><topic>Pancreatic Neoplasms - surgery</topic><topic>Uveal Neoplasms - drug therapy</topic><topic>Uveal Neoplasms - pathology</topic><topic>Uveal Neoplasms - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Camp, Ramsey</creatorcontrib><creatorcontrib>Lind, D. 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We report a patient with ocular melanoma metastatic to liver and pancreas treated by cytoreductive surgery consisting of mesohepatic resection, distal pancreatectomy, and portal node dissection, followed by biochemotherapy with dacarbazine and interferon alpha. The concept of cytoreductive surgery is reviewed, with particular attention to its use in the management of metastatic melanoma. The patient's postoperative course was unremarkable and she remains alive and asymptomatic with no detectable disease at 20 months' follow‐up. Cytoreductive surgery as a part of an aggressive multidisciplinary approach may play a role in the treatment of cutaneous and ocular melanoma metastatic to multiple visceral sites. Data from well‐designed, innovative clinical trials of cytoreductive surgery and biochemotherapy are required to determine the effectiveness of this multidisciplinary approach.</abstract><cop>Japan</cop><pmid>12483277</pmid><doi>10.1007/s005340200066</doi><tpages>3</tpages></addata></record> |
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subjects | Antineoplastic Agents, Alkylating - therapeutic use biochemotherapy cytoreductive surgery Dacarbazine - therapeutic use Eye Enucleation Female Hepatectomy Humans Interferon-alpha - therapeutic use Liver Neoplasms - secondary Liver Neoplasms - surgery Lymph Node Excision Lymphatic Metastasis Melanoma - drug therapy Melanoma - pathology Melanoma - surgery Middle Aged ocular melanoma Pancreatectomy Pancreatic Neoplasms - immunology Pancreatic Neoplasms - surgery Uveal Neoplasms - drug therapy Uveal Neoplasms - pathology Uveal Neoplasms - surgery |
title | Combined liver and pancreas resection with biochemotherapy for metastatic ocular melanoma |
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