Anti-MRSA cephems. Part 3: Additional C-7 acid derivatives

Twenty-seven novel cephalosporin derivatives with activity against methicillin-resistant Staphylococcus aureus (MRSA) are described. The compounds contain novel acid moieties at C-7 that were synthesized using nucleophilic aromatic substitution reactions and Stille couplings. The most interesting co...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2003-01, Vol.11 (2), p.281-291
Hauptverfasser:	Springer, Dane M, Luh, Bing-Yu, Goodrich, Jason T, Bronson, Joanne J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Cephalosporins - chemistry Cephalosporins - pharmacology Disease Models, Animal Lethal Dose 50 Medical sciences Methicillin Resistance Mice Microbial Sensitivity Tests Pharmacology. Drug treatments Staphylococcal Infections - microbiology Staphylococcus aureus - drug effects Staphylococcus aureus - pathogenicity Structure-Activity Relationship
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