Disulfiram induces apoptosis in human melanoma cells: a redox-related process

Melanoma is highly resistant to conventional chemotherapy. We have demonstrated that redox regulation in melanoma cells is aberrant, and redox-modulating agents can induce cell apoptosis. We have currently explored the effect of disulfiram (DSF), a member of the dithiocarbamate family, on apoptosis...

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Veröffentlicht in:	Molecular cancer therapeutics 2002-01, Vol.1 (3), p.197
Hauptverfasser:	Cen, Dazhi, Gonzalez, Rachel I, Buckmeier, Julie A, Kahlon, Ravi S, Tohidian, Nilou B, Meyskens, Jr, Frank L
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimetabolites, Antineoplastic - pharmacology Apoptosis - drug effects Buthionine Sulfoximine - pharmacology Cell Division - drug effects Disulfiram - pharmacology Enzyme Inhibitors - pharmacology Glutathione - analysis Melanocytes - chemistry Melanocytes - drug effects Melanoma - drug therapy Melanoma - pathology Membrane Potentials - drug effects Mitochondria - drug effects Mitochondria - physiology Mitochondria - ultrastructure Neoplasm Metastasis Oxidative Stress - drug effects Reactive Oxygen Species - metabolism Tumor Cells, Cultured - drug effects
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