Loss of microglial ramification in microglia-astrocyte cocultures: Involvement of adenylate cyclase, calcium, phosphatase, and Gi-protein systems

Reduction in microglial branching is a common feature in brain pathology and culminates in the transformation into small, rounded, microglia‐derived phagocytes in the presence of neural debris. The molecular factors responsible for this transformation are unknown. Here we explored the effect of diff...

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Veröffentlicht in:	Glia 2003-01, Vol.41 (1), p.50-63
Hauptverfasser:	Kalla, Roger, Bohatschek, Marion, Kloss, Christian U.A., Krol, Janna, Von Maltzan, Xenia, Raivich, Gennadij
Format:	Artikel
Sprache:	eng
Schlagworte:	activation Adenosine Triphosphate - pharmacology Adenylyl Cyclases - metabolism Animals Astrocytes - cytology Astrocytes - drug effects Astrocytes - metabolism Biological and medical sciences Bucladesine - pharmacology calcium Calcium - metabolism cAMP Cell Differentiation - drug effects Cells, Cultured Coculture Techniques Colforsin - pharmacology Dibutyryl Cyclic GMP - pharmacology Fundamental and applied biological sciences. Psychology GTP-Binding Protein alpha Subunits, Gi-Go - metabolism in vitro Ionophores - pharmacology Isolated neuron and nerve. Neuroglia Mice Mice, Inbred Strains microglia Microglia - cytology Microglia - drug effects Microglia - metabolism morphology Okadaic Acid - pharmacology Peptides - pharmacology Pertussis Toxin - pharmacology phagocytosis Phosphoric Monoester Hydrolases - metabolism Prostaglandin D2 - pharmacology Rats Rats, Wistar Uridine Triphosphate - pharmacology Vertebrates: nervous system and sense organs
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