Thiamin, selenium, and copper levels in patients with idiopathic dilated cardiomyopathy taking diuretics
To analyze the association of thiamin, selenium, and copper serum levels with cardiac function in patients with idiopathic dilated cardiomyopathy using diuretics, and also to compare them with levels in control patients with no evidence of disease. The study comprised 30 patients with heart disease...
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| Veröffentlicht in: | Arquivos brasileiros de cardiologia 2002-11, Vol.79 (5), p.454 |
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| creator | da Cunha, Sérgio Albanesi Filho, Francisco Manes da Cunha Bastos, Vera Lúcia Freire Antelo, Domingos Senra Souza, Mário Miranda de |
| description | To analyze the association of thiamin, selenium, and copper serum levels with cardiac function in patients with idiopathic dilated cardiomyopathy using diuretics, and also to compare them with levels in control patients with no evidence of disease.
The study comprised 30 patients with heart disease and 30 healthy control individuals. Thiamin was analyzed by measuring the activity of erythrocytic transketolase and the effect of thiamin pyrophosphate. Selenium and copper serum levels were measured by hydride generation and flame atomic absorption spectrophotometry, respectively.
Thiamin deficiency was observed in 10% of the control individuals and in 33% of the patients with heart disease (p=0.02). The mean selenium and copper serum levels in control individuals and patients with heart disease were, respectively, 73.2+/-9.9 microg/L (56.5 to 94.5 microg/L) and 72.3+/-14.3 microg/L (35.5 to 94 microg/L) (p=0.77); 1.1+/-0.4 mg/L (0.6 to 1.8 mg/L) and 1.2+/- 0.4 mg/L (0.6 to 2.2 mg/L) (p=0.27). No association between the levels of these nutrients and cardiac function was observed.
Thiamin deficiency was significantly more frequent in patients with heart disease. No significant difference was observed between the mean selenium and copper serum levels in control individuals and in patients with heart disease. The results suggest possible benefits with thiamin replacement in patients taking diuretics. |
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The study comprised 30 patients with heart disease and 30 healthy control individuals. Thiamin was analyzed by measuring the activity of erythrocytic transketolase and the effect of thiamin pyrophosphate. Selenium and copper serum levels were measured by hydride generation and flame atomic absorption spectrophotometry, respectively.
Thiamin deficiency was observed in 10% of the control individuals and in 33% of the patients with heart disease (p=0.02). The mean selenium and copper serum levels in control individuals and patients with heart disease were, respectively, 73.2+/-9.9 microg/L (56.5 to 94.5 microg/L) and 72.3+/-14.3 microg/L (35.5 to 94 microg/L) (p=0.77); 1.1+/-0.4 mg/L (0.6 to 1.8 mg/L) and 1.2+/- 0.4 mg/L (0.6 to 2.2 mg/L) (p=0.27). No association between the levels of these nutrients and cardiac function was observed.
Thiamin deficiency was significantly more frequent in patients with heart disease. No significant difference was observed between the mean selenium and copper serum levels in control individuals and in patients with heart disease. The results suggest possible benefits with thiamin replacement in patients taking diuretics.</description><identifier>ISSN: 0066-782X</identifier><identifier>PMID: 12447496</identifier><language>eng ; por</language><publisher>Brazil</publisher><subject>Adult ; Cardiomyopathy, Dilated - blood ; Cardiomyopathy, Dilated - drug therapy ; Copper - blood ; Diuretics - adverse effects ; Diuretics - therapeutic use ; Female ; Humans ; Male ; Nutritional Status ; Selenium - blood ; Stroke Volume ; Thiamine - blood ; Thiamine - therapeutic use ; Thiamine Deficiency - blood ; Thiamine Deficiency - chemically induced ; Thiamine Deficiency - drug therapy</subject><ispartof>Arquivos brasileiros de cardiologia, 2002-11, Vol.79 (5), p.454</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12447496$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>da Cunha, Sérgio</creatorcontrib><creatorcontrib>Albanesi Filho, Francisco Manes</creatorcontrib><creatorcontrib>da Cunha Bastos, Vera Lúcia Freire</creatorcontrib><creatorcontrib>Antelo, Domingos Senra</creatorcontrib><creatorcontrib>Souza, Mário Miranda de</creatorcontrib><title>Thiamin, selenium, and copper levels in patients with idiopathic dilated cardiomyopathy taking diuretics</title><title>Arquivos brasileiros de cardiologia</title><addtitle>Arq Bras Cardiol</addtitle><description>To analyze the association of thiamin, selenium, and copper serum levels with cardiac function in patients with idiopathic dilated cardiomyopathy using diuretics, and also to compare them with levels in control patients with no evidence of disease.
The study comprised 30 patients with heart disease and 30 healthy control individuals. Thiamin was analyzed by measuring the activity of erythrocytic transketolase and the effect of thiamin pyrophosphate. Selenium and copper serum levels were measured by hydride generation and flame atomic absorption spectrophotometry, respectively.
Thiamin deficiency was observed in 10% of the control individuals and in 33% of the patients with heart disease (p=0.02). The mean selenium and copper serum levels in control individuals and patients with heart disease were, respectively, 73.2+/-9.9 microg/L (56.5 to 94.5 microg/L) and 72.3+/-14.3 microg/L (35.5 to 94 microg/L) (p=0.77); 1.1+/-0.4 mg/L (0.6 to 1.8 mg/L) and 1.2+/- 0.4 mg/L (0.6 to 2.2 mg/L) (p=0.27). No association between the levels of these nutrients and cardiac function was observed.
Thiamin deficiency was significantly more frequent in patients with heart disease. No significant difference was observed between the mean selenium and copper serum levels in control individuals and in patients with heart disease. The results suggest possible benefits with thiamin replacement in patients taking diuretics.</description><subject>Adult</subject><subject>Cardiomyopathy, Dilated - blood</subject><subject>Cardiomyopathy, Dilated - drug therapy</subject><subject>Copper - blood</subject><subject>Diuretics - adverse effects</subject><subject>Diuretics - therapeutic use</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Nutritional Status</subject><subject>Selenium - blood</subject><subject>Stroke Volume</subject><subject>Thiamine - blood</subject><subject>Thiamine - therapeutic use</subject><subject>Thiamine Deficiency - blood</subject><subject>Thiamine Deficiency - chemically induced</subject><subject>Thiamine Deficiency - drug therapy</subject><issn>0066-782X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1j81OwzAQhH0A0VJ4BeQHaCQnttfJEVX8SZW45MCtcuwNWUhcK05AfXsioKeRvtGMZi7YWgiAzJTF24pdp_QhRFEYqa_YKi-UMqqCNevqjuxAYcsT9hhoHrbcBs_dMUYceY9f2CdOgUc7EYYp8W-aOk6ejgvpyHFPvZ1wSdhxgcPpl5_4ZD8pvC_uPOJELt2wy9b2CW__dcPqx4d695ztX59edvf7LGoFmUN0EkAIJaB1INHnWNpKGDBqGa-btvKATleFb6V2stGu1KU3rYFcgTdyw-7-auPcDOgPcaTBjqfD-bH8AYAXU2s</recordid><startdate>200211</startdate><enddate>200211</enddate><creator>da Cunha, Sérgio</creator><creator>Albanesi Filho, Francisco Manes</creator><creator>da Cunha Bastos, Vera Lúcia Freire</creator><creator>Antelo, Domingos Senra</creator><creator>Souza, Mário Miranda de</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>200211</creationdate><title>Thiamin, selenium, and copper levels in patients with idiopathic dilated cardiomyopathy taking diuretics</title><author>da Cunha, Sérgio ; Albanesi Filho, Francisco Manes ; da Cunha Bastos, Vera Lúcia Freire ; Antelo, Domingos Senra ; Souza, Mário Miranda de</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p546-ceec36600406fc63ed1e8a9076742275bf9d6ec592df35c3b5c858d7f76146d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; por</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Cardiomyopathy, Dilated - blood</topic><topic>Cardiomyopathy, Dilated - drug therapy</topic><topic>Copper - blood</topic><topic>Diuretics - adverse effects</topic><topic>Diuretics - therapeutic use</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Nutritional Status</topic><topic>Selenium - blood</topic><topic>Stroke Volume</topic><topic>Thiamine - blood</topic><topic>Thiamine - therapeutic use</topic><topic>Thiamine Deficiency - blood</topic><topic>Thiamine Deficiency - chemically induced</topic><topic>Thiamine Deficiency - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>da Cunha, Sérgio</creatorcontrib><creatorcontrib>Albanesi Filho, Francisco Manes</creatorcontrib><creatorcontrib>da Cunha Bastos, Vera Lúcia Freire</creatorcontrib><creatorcontrib>Antelo, Domingos Senra</creatorcontrib><creatorcontrib>Souza, Mário Miranda de</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Arquivos brasileiros de cardiologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>da Cunha, Sérgio</au><au>Albanesi Filho, Francisco Manes</au><au>da Cunha Bastos, Vera Lúcia Freire</au><au>Antelo, Domingos Senra</au><au>Souza, Mário Miranda de</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thiamin, selenium, and copper levels in patients with idiopathic dilated cardiomyopathy taking diuretics</atitle><jtitle>Arquivos brasileiros de cardiologia</jtitle><addtitle>Arq Bras Cardiol</addtitle><date>2002-11</date><risdate>2002</risdate><volume>79</volume><issue>5</issue><spage>454</spage><pages>454-</pages><issn>0066-782X</issn><abstract>To analyze the association of thiamin, selenium, and copper serum levels with cardiac function in patients with idiopathic dilated cardiomyopathy using diuretics, and also to compare them with levels in control patients with no evidence of disease.
The study comprised 30 patients with heart disease and 30 healthy control individuals. Thiamin was analyzed by measuring the activity of erythrocytic transketolase and the effect of thiamin pyrophosphate. Selenium and copper serum levels were measured by hydride generation and flame atomic absorption spectrophotometry, respectively.
Thiamin deficiency was observed in 10% of the control individuals and in 33% of the patients with heart disease (p=0.02). The mean selenium and copper serum levels in control individuals and patients with heart disease were, respectively, 73.2+/-9.9 microg/L (56.5 to 94.5 microg/L) and 72.3+/-14.3 microg/L (35.5 to 94 microg/L) (p=0.77); 1.1+/-0.4 mg/L (0.6 to 1.8 mg/L) and 1.2+/- 0.4 mg/L (0.6 to 2.2 mg/L) (p=0.27). No association between the levels of these nutrients and cardiac function was observed.
Thiamin deficiency was significantly more frequent in patients with heart disease. No significant difference was observed between the mean selenium and copper serum levels in control individuals and in patients with heart disease. The results suggest possible benefits with thiamin replacement in patients taking diuretics.</abstract><cop>Brazil</cop><pmid>12447496</pmid></addata></record> |
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| identifier | ISSN: 0066-782X |
| ispartof | Arquivos brasileiros de cardiologia, 2002-11, Vol.79 (5), p.454 |
| issn | 0066-782X |
| language | eng ; por |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Cardiomyopathy, Dilated - blood Cardiomyopathy, Dilated - drug therapy Copper - blood Diuretics - adverse effects Diuretics - therapeutic use Female Humans Male Nutritional Status Selenium - blood Stroke Volume Thiamine - blood Thiamine - therapeutic use Thiamine Deficiency - blood Thiamine Deficiency - chemically induced Thiamine Deficiency - drug therapy |
| title | Thiamin, selenium, and copper levels in patients with idiopathic dilated cardiomyopathy taking diuretics |
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