The retinoid X receptor-selective retinoid, LGD1069, prevents the development of estrogen receptor-negative mammary tumors in transgenic mice
Despite the effectiveness of the selective estrogen receptor (ER) modulators in preventing ER-positive breast cancer, chemopreventive agents still need to be developed for the prevention of ER-negative breast cancers. The naturally occurring retinoids are promising agents for the prevention of human...
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| Veröffentlicht in: | Cancer research (Chicago, Ill.) Ill.), 2002-11, Vol.62 (22), p.6376-6380 |
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| container_title | Cancer research (Chicago, Ill.) |
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| creator | WU, Kendall YUN ZHANG BROWN, Powel H XU, Xiao-Chun HILL, Jamal CELESTINO, Joseph KIM, Hee-Tae MOHSIN, Syed K HILSENBECK, Susan G LAMPH, William W BISSONETTE, Reid |
| description | Despite the effectiveness of the selective estrogen receptor (ER) modulators in preventing ER-positive breast cancer, chemopreventive agents still need to be developed for the prevention of ER-negative breast cancers. The naturally occurring retinoids are promising agents for the prevention of human cancers but are too toxic for long-term chronic use. We previously demonstrated that the chemopreventive effects of the retinoids could be separated from the toxicity by using an RXR-selective retinoid, LGD1069. The studies described here demonstrate that LGD1069 effectively suppresses ER-negative tumor development in mouse mammary tumor virus-erbB2 transgenic mice with minimal toxicity. These studies suggest that receptor-selective retinoids are promising agents for the prevention of breast cancer and that they may be particularly useful in preventing ER-negative breast cancer. |
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The naturally occurring retinoids are promising agents for the prevention of human cancers but are too toxic for long-term chronic use. We previously demonstrated that the chemopreventive effects of the retinoids could be separated from the toxicity by using an RXR-selective retinoid, LGD1069. The studies described here demonstrate that LGD1069 effectively suppresses ER-negative tumor development in mouse mammary tumor virus-erbB2 transgenic mice with minimal toxicity. These studies suggest that receptor-selective retinoids are promising agents for the prevention of breast cancer and that they may be particularly useful in preventing ER-negative breast cancer.</description><identifier>ISSN: 0008-5472</identifier><identifier>EISSN: 1538-7445</identifier><identifier>PMID: 12438218</identifier><identifier>CODEN: CNREA8</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Animals ; Anticarcinogenic Agents - pharmacology ; Biological and medical sciences ; Carcinogenesis, carcinogens and anticarcinogens ; Cell Division - drug effects ; Chemical agents ; Female ; Gene Expression - drug effects ; Genes, erbB-2 ; Mammary Glands, Animal - cytology ; Mammary Glands, Animal - drug effects ; Mammary Neoplasms, Experimental - genetics ; Mammary Neoplasms, Experimental - metabolism ; Mammary Neoplasms, Experimental - pathology ; Mammary Neoplasms, Experimental - prevention & control ; Mammary Tumor Virus, Mouse ; Medical sciences ; Mice ; Mice, Transgenic ; Receptors, Estrogen - physiology ; Receptors, Retinoic Acid - metabolism ; Retinoid X Receptors ; Tetrahydronaphthalenes - pharmacology ; Transcription Factors - metabolism ; Transgenes - drug effects ; Transgenes - genetics ; Tumors</subject><ispartof>Cancer research (Chicago, Ill.), 2002-11, Vol.62 (22), p.6376-6380</ispartof><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14034466$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12438218$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WU, Kendall</creatorcontrib><creatorcontrib>YUN ZHANG</creatorcontrib><creatorcontrib>BROWN, Powel H</creatorcontrib><creatorcontrib>XU, Xiao-Chun</creatorcontrib><creatorcontrib>HILL, Jamal</creatorcontrib><creatorcontrib>CELESTINO, Joseph</creatorcontrib><creatorcontrib>KIM, Hee-Tae</creatorcontrib><creatorcontrib>MOHSIN, Syed K</creatorcontrib><creatorcontrib>HILSENBECK, Susan G</creatorcontrib><creatorcontrib>LAMPH, William W</creatorcontrib><creatorcontrib>BISSONETTE, Reid</creatorcontrib><title>The retinoid X receptor-selective retinoid, LGD1069, prevents the development of estrogen receptor-negative mammary tumors in transgenic mice</title><title>Cancer research (Chicago, Ill.)</title><addtitle>Cancer Res</addtitle><description>Despite the effectiveness of the selective estrogen receptor (ER) modulators in preventing ER-positive breast cancer, chemopreventive agents still need to be developed for the prevention of ER-negative breast cancers. The naturally occurring retinoids are promising agents for the prevention of human cancers but are too toxic for long-term chronic use. We previously demonstrated that the chemopreventive effects of the retinoids could be separated from the toxicity by using an RXR-selective retinoid, LGD1069. The studies described here demonstrate that LGD1069 effectively suppresses ER-negative tumor development in mouse mammary tumor virus-erbB2 transgenic mice with minimal toxicity. These studies suggest that receptor-selective retinoids are promising agents for the prevention of breast cancer and that they may be particularly useful in preventing ER-negative breast cancer.</description><subject>Animals</subject><subject>Anticarcinogenic Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Carcinogenesis, carcinogens and anticarcinogens</subject><subject>Cell Division - drug effects</subject><subject>Chemical agents</subject><subject>Female</subject><subject>Gene Expression - drug effects</subject><subject>Genes, erbB-2</subject><subject>Mammary Glands, Animal - cytology</subject><subject>Mammary Glands, Animal - drug effects</subject><subject>Mammary Neoplasms, Experimental - genetics</subject><subject>Mammary Neoplasms, Experimental - metabolism</subject><subject>Mammary Neoplasms, Experimental - pathology</subject><subject>Mammary Neoplasms, Experimental - prevention & control</subject><subject>Mammary Tumor Virus, Mouse</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>Receptors, Estrogen - physiology</subject><subject>Receptors, Retinoic Acid - metabolism</subject><subject>Retinoid X Receptors</subject><subject>Tetrahydronaphthalenes - pharmacology</subject><subject>Transcription Factors - metabolism</subject><subject>Transgenes - drug effects</subject><subject>Transgenes - genetics</subject><subject>Tumors</subject><issn>0008-5472</issn><issn>1538-7445</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkN1KAzEQhYMotlZfQXLjXRfyv9lLqVqFgjcVvCtpftrIZndJ0oIP4TsbtbJXc2bmm8NhzsAUcyqrmjF-DqYIIVlxVpMJuErpo7QcI34JJpgwKgmWU_C13lsYbfZd7w18L1LbIfexSra1OvvjuJ3D1fIBI9HM4RDt0XY5wVyuTdFtP4QygL2DNuXY72w3WnV2p36dggpBxU-YD6GPCfoO5qi6VGCvYfDaXoMLp9pkb051Bt6eHteL52r1unxZ3K-qPalxrgw1wjmnOOVyyzRxQjYN0VQjjJgTXDmnhTBSNDVnuLaEEYpqgTnSzhDa0Bm4_fMdDttgzWaI_ifY5v8vBbg7ASpp1boSU_s0cgxRxoSg35xGbq0</recordid><startdate>20021115</startdate><enddate>20021115</enddate><creator>WU, Kendall</creator><creator>YUN ZHANG</creator><creator>BROWN, Powel H</creator><creator>XU, Xiao-Chun</creator><creator>HILL, Jamal</creator><creator>CELESTINO, Joseph</creator><creator>KIM, Hee-Tae</creator><creator>MOHSIN, Syed K</creator><creator>HILSENBECK, Susan G</creator><creator>LAMPH, William W</creator><creator>BISSONETTE, Reid</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20021115</creationdate><title>The retinoid X receptor-selective retinoid, LGD1069, prevents the development of estrogen receptor-negative mammary tumors in transgenic mice</title><author>WU, Kendall ; YUN ZHANG ; BROWN, Powel H ; XU, Xiao-Chun ; HILL, Jamal ; CELESTINO, Joseph ; KIM, Hee-Tae ; MOHSIN, Syed K ; HILSENBECK, Susan G ; LAMPH, William W ; BISSONETTE, Reid</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h271t-d3d6fffa5358b4c2f68992c3c0104f65affc66d86975417e2423076150cfd2393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Anticarcinogenic Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Carcinogenesis, carcinogens and anticarcinogens</topic><topic>Cell Division - drug effects</topic><topic>Chemical agents</topic><topic>Female</topic><topic>Gene Expression - drug effects</topic><topic>Genes, erbB-2</topic><topic>Mammary Glands, Animal - cytology</topic><topic>Mammary Glands, Animal - drug effects</topic><topic>Mammary Neoplasms, Experimental - genetics</topic><topic>Mammary Neoplasms, Experimental - metabolism</topic><topic>Mammary Neoplasms, Experimental - pathology</topic><topic>Mammary Neoplasms, Experimental - prevention & control</topic><topic>Mammary Tumor Virus, Mouse</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Transgenic</topic><topic>Receptors, Estrogen - physiology</topic><topic>Receptors, Retinoic Acid - metabolism</topic><topic>Retinoid X Receptors</topic><topic>Tetrahydronaphthalenes - pharmacology</topic><topic>Transcription Factors - metabolism</topic><topic>Transgenes - drug effects</topic><topic>Transgenes - genetics</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WU, Kendall</creatorcontrib><creatorcontrib>YUN ZHANG</creatorcontrib><creatorcontrib>BROWN, Powel H</creatorcontrib><creatorcontrib>XU, Xiao-Chun</creatorcontrib><creatorcontrib>HILL, Jamal</creatorcontrib><creatorcontrib>CELESTINO, Joseph</creatorcontrib><creatorcontrib>KIM, Hee-Tae</creatorcontrib><creatorcontrib>MOHSIN, Syed K</creatorcontrib><creatorcontrib>HILSENBECK, Susan G</creatorcontrib><creatorcontrib>LAMPH, William W</creatorcontrib><creatorcontrib>BISSONETTE, Reid</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Cancer research (Chicago, Ill.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WU, Kendall</au><au>YUN ZHANG</au><au>BROWN, Powel H</au><au>XU, Xiao-Chun</au><au>HILL, Jamal</au><au>CELESTINO, Joseph</au><au>KIM, Hee-Tae</au><au>MOHSIN, Syed K</au><au>HILSENBECK, Susan G</au><au>LAMPH, William W</au><au>BISSONETTE, Reid</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The retinoid X receptor-selective retinoid, LGD1069, prevents the development of estrogen receptor-negative mammary tumors in transgenic mice</atitle><jtitle>Cancer research (Chicago, Ill.)</jtitle><addtitle>Cancer Res</addtitle><date>2002-11-15</date><risdate>2002</risdate><volume>62</volume><issue>22</issue><spage>6376</spage><epage>6380</epage><pages>6376-6380</pages><issn>0008-5472</issn><eissn>1538-7445</eissn><coden>CNREA8</coden><abstract>Despite the effectiveness of the selective estrogen receptor (ER) modulators in preventing ER-positive breast cancer, chemopreventive agents still need to be developed for the prevention of ER-negative breast cancers. The naturally occurring retinoids are promising agents for the prevention of human cancers but are too toxic for long-term chronic use. We previously demonstrated that the chemopreventive effects of the retinoids could be separated from the toxicity by using an RXR-selective retinoid, LGD1069. The studies described here demonstrate that LGD1069 effectively suppresses ER-negative tumor development in mouse mammary tumor virus-erbB2 transgenic mice with minimal toxicity. These studies suggest that receptor-selective retinoids are promising agents for the prevention of breast cancer and that they may be particularly useful in preventing ER-negative breast cancer.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>12438218</pmid><tpages>5</tpages></addata></record> |
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| source | MEDLINE; American Association for Cancer Research; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Anticarcinogenic Agents - pharmacology Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Cell Division - drug effects Chemical agents Female Gene Expression - drug effects Genes, erbB-2 Mammary Glands, Animal - cytology Mammary Glands, Animal - drug effects Mammary Neoplasms, Experimental - genetics Mammary Neoplasms, Experimental - metabolism Mammary Neoplasms, Experimental - pathology Mammary Neoplasms, Experimental - prevention & control Mammary Tumor Virus, Mouse Medical sciences Mice Mice, Transgenic Receptors, Estrogen - physiology Receptors, Retinoic Acid - metabolism Retinoid X Receptors Tetrahydronaphthalenes - pharmacology Transcription Factors - metabolism Transgenes - drug effects Transgenes - genetics Tumors |
| title | The retinoid X receptor-selective retinoid, LGD1069, prevents the development of estrogen receptor-negative mammary tumors in transgenic mice |
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