Altered signaling and cell cycle regulation in embryonal stem cells with a disruption of the gene for phosphoinositide 3-kinase regulatory subunit p85alpha

The p85alpha regulatory subunit of class I(A) phosphoinositide 3-kinases (PI3K) is derived from the Pik3r1 gene, which also yields alternatively spliced variants p50alpha and p55alpha. It has been proposed that excess monomeric p85 competes with functional PI3K p85-p110 heterodimers. We examined emb...

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Veröffentlicht in:	The Journal of biological chemistry 2003-02, Vol.278 (7), p.5099
Hauptverfasser:	Hallmann, Daniel, Trümper, Katja, Trusheim, Heidi, Ueki, Kohjiro, Kahn, C Ronald, Cantley, Lewis C, Fruman, David A, Hörsch, Dieter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Cycle - physiology Cell Line Cyclic AMP Response Element-Binding Protein - physiology Gene Deletion Gene Expression Regulation, Developmental Insulin-Like Growth Factor I - metabolism MAP Kinase Signaling System Mice Mice, Knockout Phosphatidylinositol 3-Kinases - genetics Stem Cells - cytology Stem Cells - physiology
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