Chronic bronchial allergic inflammation increases alveolar liquid clearance by TNF-alpha -dependent mechanism
1 Institut National de la Santé et de la Recherche Médicale U416, Institut Pasteur de Lille, 59019 Lille; 2 EA2689, Institut Fédératif de Recherche 22, Université de Lille II, 59024 Lille; 3 Service d'Anatomie et de Cytologie Pathologiques, Hôpital Saint-Louis, 75010 Paris, France; and 4 De...
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| Veröffentlicht in: | American journal of physiology. Lung cellular and molecular physiology 2002-12, Vol.283 (6), p.1303-L1309 |
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| container_title | American journal of physiology. Lung cellular and molecular physiology |
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| creator | Tillie-Leblond, Isabelle Guery, Benoit P. H Janin, Anne Leberre, Rozenn Just, Nicolas Pittet, Jean-Francois Tonnel, Andre-Bernard Gosset, Philippe |
| description | 1 Institut National de la Santé et de la
Recherche Médicale U416, Institut Pasteur de Lille, 59019 Lille; 2 EA2689, Institut Fédératif de
Recherche 22, Université de Lille II, 59024 Lille;
3 Service d'Anatomie et de Cytologie Pathologiques,
Hôpital Saint-Louis, 75010 Paris, France; and
4 Departments of Anesthesia and Perioperative Care and
Surgery, University of California-San Francisco, San Francisco,
California 94143
Bronchial inflammation
in allergic asthma is associated with active exudation from the
bronchial tree into the interstitial space of both mucosa and
submucosa. The aim of this study was to evaluate epithelial and
endothelial permeability as well as alveolar fluid movement in a model
of chronic allergic inflammation in Brown-Norway rats sensitized and
challenged with ovalbumin (OA). Control groups were challenged with
saline solution (C), and rats were immunized by OA but not challenged
(Se). Lung sections showed a marked inflammatory infiltrate associated
with perivascular and peribronchiolar edema in OA. To measure alveolar
liquid clearance, a 5% bovine albumin solution with 1 µCi of
125 I-labeled human albumin was instilled into the air
spaces. Alveolar-capillary barrier permeability was evaluated by
intravascular injection of 1 µCi of 131 I-labeled albumin.
Endothelial permeability was significantly increased in OA, from
0.08 ± 0.01 in the C group to 0.19 ± 0.03 in OA group
( P |
| doi_str_mv | 10.1152/ajplung.00147.2002 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmed_primary_12388371</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72672655</sourcerecordid><originalsourceid>FETCH-LOGICAL-c389t-f8dc8bc60e89c6ff23982a5c513e197dceba9e2596277d09c2bc69246d2fc88c3</originalsourceid><addsrcrecordid>eNp1kE-P0zAQxS3Eiv37BTignLiljO06cbihirJIFVy6Z8uxJ41XjpO1E6DfHi_tCi5II82M5_2erEfIWworSgX7oB8nv4TDCoCu6xUDYK_IVT6wkgpYv84zrKGECsQluU7pEQAEQPWGXFLGpeQ1vSLDpo9jcKZoczO9077Q3mM85CcXOq-HQc9uDHkxEXXClO8_cPQ6Ft49Lc4WxqOOOhgs2mOx_7YttZ96XZQWJwwWw1wMaHodXBpuyUWnfcK7c78hD9vP-819ufv-5evm0640XDZz2UlrZGsqQNmYqusYbyTTwgjKkTa1NdjqBploKlbXFhrDsrhh68qyzkhp-A15f_Kd4vi0YJrV4JJB73XAcUmqZlUuIbKQnYQmjilF7NQU3aDjUVFQzyGrc8jqT8jqOeQMvTu7L-2A9i9yTjULPp4EvTv0P11ENfXH5EY_Ho5qu3i_x1_zizOTXFVqRzlwNdkuw6v_wy-_-QfivwG-LaGc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72672655</pqid></control><display><type>article</type><title>Chronic bronchial allergic inflammation increases alveolar liquid clearance by TNF-alpha -dependent mechanism</title><source>MEDLINE</source><source>American Physiological Society</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Tillie-Leblond, Isabelle ; Guery, Benoit P. H ; Janin, Anne ; Leberre, Rozenn ; Just, Nicolas ; Pittet, Jean-Francois ; Tonnel, Andre-Bernard ; Gosset, Philippe</creator><creatorcontrib>Tillie-Leblond, Isabelle ; Guery, Benoit P. H ; Janin, Anne ; Leberre, Rozenn ; Just, Nicolas ; Pittet, Jean-Francois ; Tonnel, Andre-Bernard ; Gosset, Philippe</creatorcontrib><description>1 Institut National de la Santé et de la
Recherche Médicale U416, Institut Pasteur de Lille, 59019 Lille; 2 EA2689, Institut Fédératif de
Recherche 22, Université de Lille II, 59024 Lille;
3 Service d'Anatomie et de Cytologie Pathologiques,
Hôpital Saint-Louis, 75010 Paris, France; and
4 Departments of Anesthesia and Perioperative Care and
Surgery, University of California-San Francisco, San Francisco,
California 94143
Bronchial inflammation
in allergic asthma is associated with active exudation from the
bronchial tree into the interstitial space of both mucosa and
submucosa. The aim of this study was to evaluate epithelial and
endothelial permeability as well as alveolar fluid movement in a model
of chronic allergic inflammation in Brown-Norway rats sensitized and
challenged with ovalbumin (OA). Control groups were challenged with
saline solution (C), and rats were immunized by OA but not challenged
(Se). Lung sections showed a marked inflammatory infiltrate associated
with perivascular and peribronchiolar edema in OA. To measure alveolar
liquid clearance, a 5% bovine albumin solution with 1 µCi of
125 I-labeled human albumin was instilled into the air
spaces. Alveolar-capillary barrier permeability was evaluated by
intravascular injection of 1 µCi of 131 I-labeled albumin.
Endothelial permeability was significantly increased in OA, from
0.08 ± 0.01 in the C group to 0.19 ± 0.03 in OA group
( P < 0.05). Final-to-initial protein ratio was also statistically higher in OA (1.6 ± 0.05) compared with C
(1.38 ± 0.03, P = 0.01) and Se groups (1.42 ± 0.03, P = 0.04). Administration of anti-tumor
necrosis factor- antibodies within the instillate significantly
decreased this ratio (1.32 ± 0.08, P = 0.003 vs. OA). To conclude, we demonstrated a tumor necrosis factor- -dependent increase in alveolar fluid movement in a model of severe bronchial allergic inflammation associated with endothelial and epithelial leakage.
asthma; allergy; alveolar clearance; permeability</description><identifier>ISSN: 1040-0605</identifier><identifier>EISSN: 1522-1504</identifier><identifier>DOI: 10.1152/ajplung.00147.2002</identifier><identifier>PMID: 12388371</identifier><language>eng</language><publisher>United States</publisher><subject>Albumins - pharmacokinetics ; Animals ; Blood-Air Barrier ; Body Fluids - metabolism ; Bronchitis - immunology ; Bronchitis - metabolism ; Bronchitis - pathology ; Capillaries - metabolism ; Capillary Permeability ; Cattle ; Chronic Disease ; Humans ; Hypersensitivity - complications ; Immunization ; Immunoglobulin E - metabolism ; Lung - metabolism ; Male ; Ovalbumin - immunology ; Pulmonary Alveoli - blood supply ; Pulmonary Alveoli - metabolism ; Rats ; Rats, Inbred BN ; Tumor Necrosis Factor-alpha - physiology</subject><ispartof>American journal of physiology. Lung cellular and molecular physiology, 2002-12, Vol.283 (6), p.1303-L1309</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-f8dc8bc60e89c6ff23982a5c513e197dceba9e2596277d09c2bc69246d2fc88c3</citedby><cites>FETCH-LOGICAL-c389t-f8dc8bc60e89c6ff23982a5c513e197dceba9e2596277d09c2bc69246d2fc88c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3026,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12388371$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tillie-Leblond, Isabelle</creatorcontrib><creatorcontrib>Guery, Benoit P. H</creatorcontrib><creatorcontrib>Janin, Anne</creatorcontrib><creatorcontrib>Leberre, Rozenn</creatorcontrib><creatorcontrib>Just, Nicolas</creatorcontrib><creatorcontrib>Pittet, Jean-Francois</creatorcontrib><creatorcontrib>Tonnel, Andre-Bernard</creatorcontrib><creatorcontrib>Gosset, Philippe</creatorcontrib><title>Chronic bronchial allergic inflammation increases alveolar liquid clearance by TNF-alpha -dependent mechanism</title><title>American journal of physiology. Lung cellular and molecular physiology</title><addtitle>Am J Physiol Lung Cell Mol Physiol</addtitle><description>1 Institut National de la Santé et de la
Recherche Médicale U416, Institut Pasteur de Lille, 59019 Lille; 2 EA2689, Institut Fédératif de
Recherche 22, Université de Lille II, 59024 Lille;
3 Service d'Anatomie et de Cytologie Pathologiques,
Hôpital Saint-Louis, 75010 Paris, France; and
4 Departments of Anesthesia and Perioperative Care and
Surgery, University of California-San Francisco, San Francisco,
California 94143
Bronchial inflammation
in allergic asthma is associated with active exudation from the
bronchial tree into the interstitial space of both mucosa and
submucosa. The aim of this study was to evaluate epithelial and
endothelial permeability as well as alveolar fluid movement in a model
of chronic allergic inflammation in Brown-Norway rats sensitized and
challenged with ovalbumin (OA). Control groups were challenged with
saline solution (C), and rats were immunized by OA but not challenged
(Se). Lung sections showed a marked inflammatory infiltrate associated
with perivascular and peribronchiolar edema in OA. To measure alveolar
liquid clearance, a 5% bovine albumin solution with 1 µCi of
125 I-labeled human albumin was instilled into the air
spaces. Alveolar-capillary barrier permeability was evaluated by
intravascular injection of 1 µCi of 131 I-labeled albumin.
Endothelial permeability was significantly increased in OA, from
0.08 ± 0.01 in the C group to 0.19 ± 0.03 in OA group
( P < 0.05). Final-to-initial protein ratio was also statistically higher in OA (1.6 ± 0.05) compared with C
(1.38 ± 0.03, P = 0.01) and Se groups (1.42 ± 0.03, P = 0.04). Administration of anti-tumor
necrosis factor- antibodies within the instillate significantly
decreased this ratio (1.32 ± 0.08, P = 0.003 vs. OA). To conclude, we demonstrated a tumor necrosis factor- -dependent increase in alveolar fluid movement in a model of severe bronchial allergic inflammation associated with endothelial and epithelial leakage.
asthma; allergy; alveolar clearance; permeability</description><subject>Albumins - pharmacokinetics</subject><subject>Animals</subject><subject>Blood-Air Barrier</subject><subject>Body Fluids - metabolism</subject><subject>Bronchitis - immunology</subject><subject>Bronchitis - metabolism</subject><subject>Bronchitis - pathology</subject><subject>Capillaries - metabolism</subject><subject>Capillary Permeability</subject><subject>Cattle</subject><subject>Chronic Disease</subject><subject>Humans</subject><subject>Hypersensitivity - complications</subject><subject>Immunization</subject><subject>Immunoglobulin E - metabolism</subject><subject>Lung - metabolism</subject><subject>Male</subject><subject>Ovalbumin - immunology</subject><subject>Pulmonary Alveoli - blood supply</subject><subject>Pulmonary Alveoli - metabolism</subject><subject>Rats</subject><subject>Rats, Inbred BN</subject><subject>Tumor Necrosis Factor-alpha - physiology</subject><issn>1040-0605</issn><issn>1522-1504</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE-P0zAQxS3Eiv37BTignLiljO06cbihirJIFVy6Z8uxJ41XjpO1E6DfHi_tCi5II82M5_2erEfIWworSgX7oB8nv4TDCoCu6xUDYK_IVT6wkgpYv84zrKGECsQluU7pEQAEQPWGXFLGpeQ1vSLDpo9jcKZoczO9077Q3mM85CcXOq-HQc9uDHkxEXXClO8_cPQ6Ft49Lc4WxqOOOhgs2mOx_7YttZ96XZQWJwwWw1wMaHodXBpuyUWnfcK7c78hD9vP-819ufv-5evm0640XDZz2UlrZGsqQNmYqusYbyTTwgjKkTa1NdjqBploKlbXFhrDsrhh68qyzkhp-A15f_Kd4vi0YJrV4JJB73XAcUmqZlUuIbKQnYQmjilF7NQU3aDjUVFQzyGrc8jqT8jqOeQMvTu7L-2A9i9yTjULPp4EvTv0P11ENfXH5EY_Ho5qu3i_x1_zizOTXFVqRzlwNdkuw6v_wy-_-QfivwG-LaGc</recordid><startdate>20021201</startdate><enddate>20021201</enddate><creator>Tillie-Leblond, Isabelle</creator><creator>Guery, Benoit P. 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H ; Janin, Anne ; Leberre, Rozenn ; Just, Nicolas ; Pittet, Jean-Francois ; Tonnel, Andre-Bernard ; Gosset, Philippe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-f8dc8bc60e89c6ff23982a5c513e197dceba9e2596277d09c2bc69246d2fc88c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Albumins - pharmacokinetics</topic><topic>Animals</topic><topic>Blood-Air Barrier</topic><topic>Body Fluids - metabolism</topic><topic>Bronchitis - immunology</topic><topic>Bronchitis - metabolism</topic><topic>Bronchitis - pathology</topic><topic>Capillaries - metabolism</topic><topic>Capillary Permeability</topic><topic>Cattle</topic><topic>Chronic Disease</topic><topic>Humans</topic><topic>Hypersensitivity - complications</topic><topic>Immunization</topic><topic>Immunoglobulin E - metabolism</topic><topic>Lung - metabolism</topic><topic>Male</topic><topic>Ovalbumin - immunology</topic><topic>Pulmonary Alveoli - blood supply</topic><topic>Pulmonary Alveoli - metabolism</topic><topic>Rats</topic><topic>Rats, Inbred BN</topic><topic>Tumor Necrosis Factor-alpha - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tillie-Leblond, Isabelle</creatorcontrib><creatorcontrib>Guery, Benoit P. H</creatorcontrib><creatorcontrib>Janin, Anne</creatorcontrib><creatorcontrib>Leberre, Rozenn</creatorcontrib><creatorcontrib>Just, Nicolas</creatorcontrib><creatorcontrib>Pittet, Jean-Francois</creatorcontrib><creatorcontrib>Tonnel, Andre-Bernard</creatorcontrib><creatorcontrib>Gosset, Philippe</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology. Lung cellular and molecular physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tillie-Leblond, Isabelle</au><au>Guery, Benoit P. H</au><au>Janin, Anne</au><au>Leberre, Rozenn</au><au>Just, Nicolas</au><au>Pittet, Jean-Francois</au><au>Tonnel, Andre-Bernard</au><au>Gosset, Philippe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic bronchial allergic inflammation increases alveolar liquid clearance by TNF-alpha -dependent mechanism</atitle><jtitle>American journal of physiology. Lung cellular and molecular physiology</jtitle><addtitle>Am J Physiol Lung Cell Mol Physiol</addtitle><date>2002-12-01</date><risdate>2002</risdate><volume>283</volume><issue>6</issue><spage>1303</spage><epage>L1309</epage><pages>1303-L1309</pages><issn>1040-0605</issn><eissn>1522-1504</eissn><abstract>1 Institut National de la Santé et de la
Recherche Médicale U416, Institut Pasteur de Lille, 59019 Lille; 2 EA2689, Institut Fédératif de
Recherche 22, Université de Lille II, 59024 Lille;
3 Service d'Anatomie et de Cytologie Pathologiques,
Hôpital Saint-Louis, 75010 Paris, France; and
4 Departments of Anesthesia and Perioperative Care and
Surgery, University of California-San Francisco, San Francisco,
California 94143
Bronchial inflammation
in allergic asthma is associated with active exudation from the
bronchial tree into the interstitial space of both mucosa and
submucosa. The aim of this study was to evaluate epithelial and
endothelial permeability as well as alveolar fluid movement in a model
of chronic allergic inflammation in Brown-Norway rats sensitized and
challenged with ovalbumin (OA). Control groups were challenged with
saline solution (C), and rats were immunized by OA but not challenged
(Se). Lung sections showed a marked inflammatory infiltrate associated
with perivascular and peribronchiolar edema in OA. To measure alveolar
liquid clearance, a 5% bovine albumin solution with 1 µCi of
125 I-labeled human albumin was instilled into the air
spaces. Alveolar-capillary barrier permeability was evaluated by
intravascular injection of 1 µCi of 131 I-labeled albumin.
Endothelial permeability was significantly increased in OA, from
0.08 ± 0.01 in the C group to 0.19 ± 0.03 in OA group
( P < 0.05). Final-to-initial protein ratio was also statistically higher in OA (1.6 ± 0.05) compared with C
(1.38 ± 0.03, P = 0.01) and Se groups (1.42 ± 0.03, P = 0.04). Administration of anti-tumor
necrosis factor- antibodies within the instillate significantly
decreased this ratio (1.32 ± 0.08, P = 0.003 vs. OA). To conclude, we demonstrated a tumor necrosis factor- -dependent increase in alveolar fluid movement in a model of severe bronchial allergic inflammation associated with endothelial and epithelial leakage.
asthma; allergy; alveolar clearance; permeability</abstract><cop>United States</cop><pmid>12388371</pmid><doi>10.1152/ajplung.00147.2002</doi></addata></record> |
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| ispartof | American journal of physiology. Lung cellular and molecular physiology, 2002-12, Vol.283 (6), p.1303-L1309 |
| issn | 1040-0605 1522-1504 |
| language | eng |
| recordid | cdi_pubmed_primary_12388371 |
| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Albumins - pharmacokinetics Animals Blood-Air Barrier Body Fluids - metabolism Bronchitis - immunology Bronchitis - metabolism Bronchitis - pathology Capillaries - metabolism Capillary Permeability Cattle Chronic Disease Humans Hypersensitivity - complications Immunization Immunoglobulin E - metabolism Lung - metabolism Male Ovalbumin - immunology Pulmonary Alveoli - blood supply Pulmonary Alveoli - metabolism Rats Rats, Inbred BN Tumor Necrosis Factor-alpha - physiology |
| title | Chronic bronchial allergic inflammation increases alveolar liquid clearance by TNF-alpha -dependent mechanism |
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