Isolation of a novel human gene, APCDD1, as a direct target of the β-catenin/ T-cell factor 4 complex with probable involvement in colorectal carcinogenesis

To clarify the molecular mechanisms of human carcinogenesis associated with abnormal beta-catenin/T-cell factor (Tcf) signaling, we have been using cDNA microarrays to search for genes whose expression is significantly altered after introduction of wild-type APC into SW480 colon cancer cells. These...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2002-10, Vol.62 (20), p.5651-5656
Hauptverfasser:	TAKAHASHI, Meiko, FUJITA, Manabu, FURUKAWA, Yoichi, HAMAMOTO, Ryuji, SHIMOKAWA, Takashi, MIWA, Nobutomo, OGAWA, Michio, NAKAMURA, Yusuke
Format:	Artikel
Sprache:	eng
Schlagworte:	beta Catenin Biological and medical sciences Cell Division - physiology Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Colonic Neoplasms - genetics Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Cytoskeletal Proteins - genetics Cytoskeletal Proteins - metabolism Cytoskeletal Proteins - physiology DNA, Complementary - genetics DNA, Complementary - isolation & purification Epithelial Cells - pathology Fundamental and applied biological sciences. Psychology Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Regulation, Neoplastic Genes, APC - physiology HeLa Cells Humans Medical sciences Molecular and cellular biology Promoter Regions, Genetic Stomach. Duodenum. Small intestine. Colon. Rectum. Anus TCF Transcription Factors Trans-Activators - genetics Trans-Activators - metabolism Trans-Activators - physiology Transcription Factor 7-Like 2 Protein Transcription Factors - genetics Transcription Factors - metabolism Transcription Factors - physiology Tumor Cells, Cultured Tumors
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