GABA A receptor alpha-1 subunit deletion alters receptor subtype assembly, pharmacological and behavioral responses to benzodiazepines and zolpidem

Potentiation of GABA A receptor activation through allosteric benzodiazepine (BZ) sites produces the anxiolytic, anticonvulsant and sedative/hypnotic effects of BZs. Using a mouse line lacking α1 subunit expression, we investigated the contribution of the α1 subunit to GABA A receptor pharmacology,...

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Veröffentlicht in:	Neuropharmacology 2002-09, Vol.43 (4), p.685-694
Hauptverfasser:	Kralic, J.E., O’Buckley, T.K., Khisti, R.T., Hodge, C.W., Homanics, G.E., Morrow, A.L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Anxiety Agents - pharmacology Anticonvulsants - pharmacology Behavior, Animal - drug effects Benzodiazepines - pharmacology Chlorides - metabolism Diazepam Diazepam - pharmacology Exploratory Behavior - drug effects Female Flunitrazepam Flunitrazepam - metabolism GABA GABA Agonists - pharmacology GABA Modulators - metabolism Gene Deletion Hypnotics and Sedatives - pharmacology Male Mice Mice, Knockout Motor Activity - drug effects Muscimol - pharmacology Postural Balance - drug effects Pyridines - pharmacology Radioligand Assay Receptors, GABA-A - biosynthesis Receptors, GABA-A - genetics Sedation Seizure Seizures - chemically induced Seizures - physiopathology Zolpidem
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