4-hydroxynonenal induces glutamate cysteine ligase through JNK in HBE1 cells

Glutathione is the most abundant non-protein thiol in the cell, with roles in cell cycle regulation, detoxification of xenobiotics, and maintaining the redox tone of the cell. The glutathione content is controlled at several levels, the most important being the rate of de novo synthesis, which is me...

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Veröffentlicht in:	Free radical biology & medicine 2002-10, Vol.33 (7), p.974
Hauptverfasser:	Dickinson, Dale A, Iles, Karen E, Watanabe, Nobuo, Iwamoto, Takeo, Zhang, Hongqiao, Krzywanski, David M, Forman, Henry Jay
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes - pharmacology Cell Line Enzyme Induction - drug effects Glutamate-Cysteine Ligase - biosynthesis Glutamate-Cysteine Ligase - genetics Glutathione - metabolism Growth Inhibitors - pharmacology Humans JNK Mitogen-Activated Protein Kinases Kinetics Mitogen-Activated Protein Kinases - metabolism Phosphorylation Proto-Oncogene Proteins c-jun - metabolism
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