Moderate iron overload enhances lipid peroxidation in livers of rats, but does not affect NF-kappaB activation induced by the peroxisome proliferator, Wy-14,643

It has been hypothesized that high concentrations of tissue iron may enhance carcinogenesis induced by free radical mechanisms. Wy-14,643 is a peroxisome proliferator that is hepatocarcinogenic in rats. Tumor induction may result in part from excessive production of reactive oxygen species, particul...

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Veröffentlicht in:	The Journal of nutrition 2002-09, Vol.132 (9), p.2525
Hauptverfasser:	Fischer, Joan G, Glauert, Howard P, Yin, Taofei, Sweeney-Reeves, Mary L, Larmonier, Nicolas, Black, Marsha C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals DNA - drug effects DNA Damage Iron Overload - metabolism Iron, Dietary - administration & dosage Iron, Dietary - adverse effects Lipid Peroxidation - drug effects Liver - drug effects Liver - metabolism Liver Neoplasms - etiology Male NF-kappa B - metabolism Oxidative Stress Peroxisome Proliferators - pharmacology Pyrimidines - pharmacology Random Allocation Rats Rats, Sprague-Dawley Thiobarbituric Acid Reactive Substances - analysis
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