Identification of a Human Telomerase Reverse Transcriptase Peptide of Low Affinity for HLA A2.1 That Induces Cytotoxic T Lymphocytes and Mediates Lysis of Tumor Cells

Telomerase reverse transcriptase (TRT) is a tumor-associated antigen expressed in the vast majority of human tumors and is presently one of the most promising target candidates for a therapeutic cancer vaccine. TRT is also expressed at low level in selected tissues and should be considered a self an...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2002-09, Vol.99 (19), p.12275-12280
Hauptverfasser:	Hernández, Javier, García-Pons, Francisco, Lone, Yu Chun, Firat, Huseyin, Schmidt, Joseph D., Langlade-Demoyen, Pierre, Zanetti, Maurizio
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Amino Acid Sequence Amino Acid Substitution Animals Antigen Presentation Antigens B lymphocytes B-Lymphocytes - immunology Binding Sites Biological Sciences Cancer Cancer Vaccines - genetics Cancer Vaccines - pharmacology Cell lines Cells Cross Reactions Cytotoxicity, Immunologic - drug effects DNA-Binding Proteins HeLa Cells HLA antigens HLA-A2 Antigen - metabolism Humans Immune response Immunology In Vitro Techniques Kinetics Male Mice Mice, Inbred C57BL Mice, Transgenic Molecules Peptide Fragments - genetics Peptide Fragments - immunology Peptide Fragments - metabolism Peptide Fragments - pharmacology Peptides Prostatic Neoplasms - immunology Prostatic Neoplasms - therapy T lymphocytes T-Lymphocytes, Cytotoxic - drug effects T-Lymphocytes, Cytotoxic - immunology Telomerase - genetics Telomerase - immunology Telomerase - metabolism Telomerase - pharmacology Tumor Cells, Cultured Tumors
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