Synthesis of (-)-5,8-dihydroxy-3R-methyl-2R-(dipropylamino)-1,2,3,4-tetrahydronaphthalene: an inhibitor of beta-amyloid(1-42) aggregation

A concise synthesis of the beta-amyloid(1-42 )aggregation inhibitor (-)-5,8-dihydroxy-3R-methyl-2R-(dipropylamino)-1,2,3,4-tetrahydronaphthalene [(-)-2] has been developed. The key step is a regio- and diastereoselective hydroboration-amination sequence to convert alkene into amine. Enantiomeric res...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2002-11, Vol.10 (11), p.3565
Hauptverfasser:	Parker, Michael H, Chen, Robert, Conway, Kelly A, Lee, Daniel H S, Luo, Chi, Boyd, Robert E, Nortey, Samuel O, Ross, Tina M, Scott, Malcolm K, Reitz, Allen B
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid beta-Peptides - drug effects Antioxidants - pharmacology Chromatography, High Pressure Liquid Crystallization Crystallography, X-Ray Fluorescent Dyes Hydroquinones - pharmacology Indicators and Reagents Magnetic Resonance Spectroscopy Peptide Fragments - drug effects Stereoisomerism Structure-Activity Relationship Tetrahydronaphthalenes - chemical synthesis Tetrahydronaphthalenes - pharmacology Thiazoles - chemistry
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