Isosorbide-based aspirin prodrugs: II. Hydrolysis kinetics of isosorbide diaspirinate

Aspirin prodrugs have been intensively investigated in an effort to produce compounds with lower gastric toxicity, greater stability or enhanced percutaneous absorption, relative to aspirin. This report describes the hydrolysis kinetics and aspirin release characteristics of isosorbide diaspirinate...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2002-09, Vol.16 (4), p.297-304
Hauptverfasser:	Gilmer, John F, Moriarty, Louise M, Lally, Maeve N, Clancy, John M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aspirin Aspirin - analogs & derivatives Aspirin - chemical synthesis Aspirin - chemistry Aspirin - metabolism Butyrylcholinesterase Butyrylcholinesterase - blood Catalysis Chromatography, High Pressure Liquid Female Humans Hydrogen-Ion Concentration Hydrolysis In Vitro Techniques Isosorbide Isosorbide - analogs & derivatives Isosorbide - chemical synthesis Isosorbide - chemistry Isosorbide - metabolism Kinetics Male Prodrug Prodrugs - chemical synthesis Prodrugs - chemistry Prodrugs - metabolism Time Factors
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