Effects of anaesthetic agents on gastrin-stimulated and histamine-stimulated gastric acid secretion in the totally isolated vascularly perfused rat stomach
Anaesthetic agents affect gastric acid secretion, but the mechanisms behind this action have not been fully evaluated. The enterochromaffin-like (ECL) cell plays a key role in the regulation of gastric acid secretion, and anaesthetic agents have recently been described as inhibiting histamine releas...
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| Veröffentlicht in: | Scandinavian journal of gastroenterology 2002-07, Vol.37 (7), p.750-753 |
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| container_title | Scandinavian journal of gastroenterology |
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| creator | CUI, G.-L SANDVIK, A. K MUNKVOLD, B WALDUM, H. L |
| description | Anaesthetic agents affect gastric acid secretion, but the mechanisms behind this action have not been fully evaluated. The enterochromaffin-like (ECL) cell plays a key role in the regulation of gastric acid secretion, and anaesthetic agents have recently been described as inhibiting histamine release from the ECL cell. The present study examines the effect of anaesthetic agents on the ECL cell and on parietal cell functions.
Different concentrations of urethane, pentobarbital and a mixture of fluanisone/fantanyl/midazolam (FFM) were examined for the effect on gastrin-stimulated histamine release and acid secretion and on histamine-stimulated acid secretion in the totally isolated vascularly perfused rat stomach. The luminal acid output and histamine concentrations in venous effluents were measured by titration and radioimmunoassay, respectively.
Pentobarbital caused an inhibition on both histamine release and acid output in gastrin-stimulated stomachs in a concentration-dependent way. The mixture of FFM at higher concentrations inhibited histamine release from the ECL cell and luminal H+ output in gastrin-stimulated acid secretion. Urethane exerted a slight inhibitory effect on histamine release only at the lowest concentration. Pentobarbital also reduced histamine-stimulated gastric acid secretion, while the mixture of FFM did not.
pentobarbital inhibits acid secretion both by reducing ECL cell histamine release and parietal cell H+ secretion, whereas FFM inhibits acid secretion by interaction with the ECL cell only. Urethane also had a slight inhibitory effect on the ECL cell histamine release at the lowest concentration. |
| doi_str_mv | 10.1080/00365520213249 |
| format | Article |
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Different concentrations of urethane, pentobarbital and a mixture of fluanisone/fantanyl/midazolam (FFM) were examined for the effect on gastrin-stimulated histamine release and acid secretion and on histamine-stimulated acid secretion in the totally isolated vascularly perfused rat stomach. The luminal acid output and histamine concentrations in venous effluents were measured by titration and radioimmunoassay, respectively.
Pentobarbital caused an inhibition on both histamine release and acid output in gastrin-stimulated stomachs in a concentration-dependent way. The mixture of FFM at higher concentrations inhibited histamine release from the ECL cell and luminal H+ output in gastrin-stimulated acid secretion. Urethane exerted a slight inhibitory effect on histamine release only at the lowest concentration. Pentobarbital also reduced histamine-stimulated gastric acid secretion, while the mixture of FFM did not.
pentobarbital inhibits acid secretion both by reducing ECL cell histamine release and parietal cell H+ secretion, whereas FFM inhibits acid secretion by interaction with the ECL cell only. Urethane also had a slight inhibitory effect on the ECL cell histamine release at the lowest concentration.</description><identifier>ISSN: 0036-5521</identifier><identifier>EISSN: 1502-7708</identifier><identifier>DOI: 10.1080/00365520213249</identifier><identifier>PMID: 12190085</identifier><identifier>CODEN: SJGRA4</identifier><language>eng</language><publisher>Copenhagen: Scandinavian University Press</publisher><subject>Anesthetics, Combined - administration & dosage ; Anesthetics, Combined - pharmacology ; Anesthetics, Intravenous - administration & dosage ; Anesthetics, Intravenous - pharmacology ; Anesthetics. Neuromuscular blocking agents ; Animals ; Biological and medical sciences ; Enterochromaffin-like Cells - drug effects ; Gastric Acid - metabolism ; Gastric Mucosa - drug effects ; Gastric Mucosa - physiology ; Gastrins - physiology ; Histamine - physiology ; Histamine Release - drug effects ; Male ; Medical sciences ; Models, Animal ; Neuropharmacology ; Parietal Cells, Gastric - drug effects ; Pentobarbital - administration & dosage ; Pentobarbital - pharmacology ; Pharmacology. Drug treatments ; Rats ; Rats, Wistar ; Stomach - drug effects ; Stomach - physiology ; Urethane - administration & dosage ; Urethane - pharmacology</subject><ispartof>Scandinavian journal of gastroenterology, 2002-07, Vol.37 (7), p.750-753</ispartof><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14576355$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12190085$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CUI, G.-L</creatorcontrib><creatorcontrib>SANDVIK, A. K</creatorcontrib><creatorcontrib>MUNKVOLD, B</creatorcontrib><creatorcontrib>WALDUM, H. L</creatorcontrib><title>Effects of anaesthetic agents on gastrin-stimulated and histamine-stimulated gastric acid secretion in the totally isolated vascularly perfused rat stomach</title><title>Scandinavian journal of gastroenterology</title><addtitle>Scand J Gastroenterol</addtitle><description>Anaesthetic agents affect gastric acid secretion, but the mechanisms behind this action have not been fully evaluated. The enterochromaffin-like (ECL) cell plays a key role in the regulation of gastric acid secretion, and anaesthetic agents have recently been described as inhibiting histamine release from the ECL cell. The present study examines the effect of anaesthetic agents on the ECL cell and on parietal cell functions.
Different concentrations of urethane, pentobarbital and a mixture of fluanisone/fantanyl/midazolam (FFM) were examined for the effect on gastrin-stimulated histamine release and acid secretion and on histamine-stimulated acid secretion in the totally isolated vascularly perfused rat stomach. The luminal acid output and histamine concentrations in venous effluents were measured by titration and radioimmunoassay, respectively.
Pentobarbital caused an inhibition on both histamine release and acid output in gastrin-stimulated stomachs in a concentration-dependent way. The mixture of FFM at higher concentrations inhibited histamine release from the ECL cell and luminal H+ output in gastrin-stimulated acid secretion. Urethane exerted a slight inhibitory effect on histamine release only at the lowest concentration. Pentobarbital also reduced histamine-stimulated gastric acid secretion, while the mixture of FFM did not.
pentobarbital inhibits acid secretion both by reducing ECL cell histamine release and parietal cell H+ secretion, whereas FFM inhibits acid secretion by interaction with the ECL cell only. Urethane also had a slight inhibitory effect on the ECL cell histamine release at the lowest concentration.</description><subject>Anesthetics, Combined - administration & dosage</subject><subject>Anesthetics, Combined - pharmacology</subject><subject>Anesthetics, Intravenous - administration & dosage</subject><subject>Anesthetics, Intravenous - pharmacology</subject><subject>Anesthetics. Neuromuscular blocking agents</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Enterochromaffin-like Cells - drug effects</subject><subject>Gastric Acid - metabolism</subject><subject>Gastric Mucosa - drug effects</subject><subject>Gastric Mucosa - physiology</subject><subject>Gastrins - physiology</subject><subject>Histamine - physiology</subject><subject>Histamine Release - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Models, Animal</subject><subject>Neuropharmacology</subject><subject>Parietal Cells, Gastric - drug effects</subject><subject>Pentobarbital - administration & dosage</subject><subject>Pentobarbital - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Stomach - drug effects</subject><subject>Stomach - physiology</subject><subject>Urethane - administration & dosage</subject><subject>Urethane - pharmacology</subject><issn>0036-5521</issn><issn>1502-7708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkE1LAzEQhoMotlavHiUXj6uTZLNJj1LqBxS86LnMZpM2sl8kqdDf4p810oqeBt73mYdhCLlmcMdAwz2AqKTkwJng5fyETJkEXigF-pRMf8oit2xCLmL8AACpyvk5mTDO5gBaTsnX0jlrUqSDo9ijjWlrkzcUN7b_SXu6wZiC74uYfLdrMdkmgw3d-piw8739XxzYvG18Q6M1Ibuywvc0a2kaErbtnvo4HPBPjCZvhpyNNrhdzFnARGMaOjTbS3LmsI326jhn5P1x-bZ4LlavTy-Lh1UxcqFSIa2tKs5BO1M3tWIg0aI2xjRGQWlrzUulXdMA10rJmhlbouZSCSccugrEjNwcvOOu7myzHoPvMOzXv1_KwO0RyAdj6wL2xsc_rpSqElKKb710ez0</recordid><startdate>20020701</startdate><enddate>20020701</enddate><creator>CUI, G.-L</creator><creator>SANDVIK, A. K</creator><creator>MUNKVOLD, B</creator><creator>WALDUM, H. L</creator><general>Scandinavian University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20020701</creationdate><title>Effects of anaesthetic agents on gastrin-stimulated and histamine-stimulated gastric acid secretion in the totally isolated vascularly perfused rat stomach</title><author>CUI, G.-L ; SANDVIK, A. K ; MUNKVOLD, B ; WALDUM, H. L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p237t-5ee662208fcbdb7105aea8cccdc704eb82478fdd028775b1ce4a82573f3faf603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Anesthetics, Combined - administration & dosage</topic><topic>Anesthetics, Combined - pharmacology</topic><topic>Anesthetics, Intravenous - administration & dosage</topic><topic>Anesthetics, Intravenous - pharmacology</topic><topic>Anesthetics. Neuromuscular blocking agents</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Enterochromaffin-like Cells - drug effects</topic><topic>Gastric Acid - metabolism</topic><topic>Gastric Mucosa - drug effects</topic><topic>Gastric Mucosa - physiology</topic><topic>Gastrins - physiology</topic><topic>Histamine - physiology</topic><topic>Histamine Release - drug effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Models, Animal</topic><topic>Neuropharmacology</topic><topic>Parietal Cells, Gastric - drug effects</topic><topic>Pentobarbital - administration & dosage</topic><topic>Pentobarbital - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Stomach - drug effects</topic><topic>Stomach - physiology</topic><topic>Urethane - administration & dosage</topic><topic>Urethane - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CUI, G.-L</creatorcontrib><creatorcontrib>SANDVIK, A. K</creatorcontrib><creatorcontrib>MUNKVOLD, B</creatorcontrib><creatorcontrib>WALDUM, H. L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Scandinavian journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CUI, G.-L</au><au>SANDVIK, A. K</au><au>MUNKVOLD, B</au><au>WALDUM, H. L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of anaesthetic agents on gastrin-stimulated and histamine-stimulated gastric acid secretion in the totally isolated vascularly perfused rat stomach</atitle><jtitle>Scandinavian journal of gastroenterology</jtitle><addtitle>Scand J Gastroenterol</addtitle><date>2002-07-01</date><risdate>2002</risdate><volume>37</volume><issue>7</issue><spage>750</spage><epage>753</epage><pages>750-753</pages><issn>0036-5521</issn><eissn>1502-7708</eissn><coden>SJGRA4</coden><abstract>Anaesthetic agents affect gastric acid secretion, but the mechanisms behind this action have not been fully evaluated. The enterochromaffin-like (ECL) cell plays a key role in the regulation of gastric acid secretion, and anaesthetic agents have recently been described as inhibiting histamine release from the ECL cell. The present study examines the effect of anaesthetic agents on the ECL cell and on parietal cell functions.
Different concentrations of urethane, pentobarbital and a mixture of fluanisone/fantanyl/midazolam (FFM) were examined for the effect on gastrin-stimulated histamine release and acid secretion and on histamine-stimulated acid secretion in the totally isolated vascularly perfused rat stomach. The luminal acid output and histamine concentrations in venous effluents were measured by titration and radioimmunoassay, respectively.
Pentobarbital caused an inhibition on both histamine release and acid output in gastrin-stimulated stomachs in a concentration-dependent way. The mixture of FFM at higher concentrations inhibited histamine release from the ECL cell and luminal H+ output in gastrin-stimulated acid secretion. Urethane exerted a slight inhibitory effect on histamine release only at the lowest concentration. Pentobarbital also reduced histamine-stimulated gastric acid secretion, while the mixture of FFM did not.
pentobarbital inhibits acid secretion both by reducing ECL cell histamine release and parietal cell H+ secretion, whereas FFM inhibits acid secretion by interaction with the ECL cell only. Urethane also had a slight inhibitory effect on the ECL cell histamine release at the lowest concentration.</abstract><cop>Copenhagen</cop><cop>Oslo</cop><cop>Stockholm</cop><pub>Scandinavian University Press</pub><pmid>12190085</pmid><doi>10.1080/00365520213249</doi><tpages>4</tpages></addata></record> |
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| source | Taylor & Francis:Master (3349 titles); MEDLINE; Taylor & Francis Medical Library - CRKN |
| subjects | Anesthetics, Combined - administration & dosage Anesthetics, Combined - pharmacology Anesthetics, Intravenous - administration & dosage Anesthetics, Intravenous - pharmacology Anesthetics. Neuromuscular blocking agents Animals Biological and medical sciences Enterochromaffin-like Cells - drug effects Gastric Acid - metabolism Gastric Mucosa - drug effects Gastric Mucosa - physiology Gastrins - physiology Histamine - physiology Histamine Release - drug effects Male Medical sciences Models, Animal Neuropharmacology Parietal Cells, Gastric - drug effects Pentobarbital - administration & dosage Pentobarbital - pharmacology Pharmacology. Drug treatments Rats Rats, Wistar Stomach - drug effects Stomach - physiology Urethane - administration & dosage Urethane - pharmacology |
| title | Effects of anaesthetic agents on gastrin-stimulated and histamine-stimulated gastric acid secretion in the totally isolated vascularly perfused rat stomach |
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