SUBCHRONIC ADMINISTRATION OF PYRIDOSTIGMINE OR HUPERZINE TO PRIMATES: COMPARED EFFICACY AGAINST SOMAN TOXICITY

ABSTRACT Organophosphonate (OP) nerve agents, such as soman, are potent irreversible inhibitors of central and peripheral acetylcholinesterases (AChEs). Pre-treatment of OP poisoning relies on the subchronic administration of a reversible AChE inhibitor. In the present limited study, the protective...

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Veröffentlicht in:	Drug and chemical toxicology (New York, N.Y. 1978) N.Y. 1978), 2002-01, Vol.25 (3), p.309-320
Hauptverfasser:	Lallement, Guy, Demoncheaux, Jean-Paul, Foquin, Annie, Baubichon, Dominique, Galonnier, Monique, Clarençon, Didier, Dorandeu, Frédéric
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids Animals Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Chemical Warfare Agents - toxicity Cholinesterase Inhibitors - pharmacology Huperzine Macaca fascicularis Male Medical sciences Organophosphonate poisoning Primates Pyridostigmine Pyridostigmine Bromide - pharmacology Seizures Seizures - chemically induced Seizures - prevention & control Sesquiterpenes - pharmacology Soman - toxicity Toxicology Various organic compounds
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