A p34(cdc2) survival checkpoint in cancer

A checkpoint surveying the entry into mitosis responds to defects in spindle microtubule assembly/stability. This has been used to trigger apoptosis in cancer cells, but how the spindle checkpoint couples to the cell survival machinery has remained elusive. Here, we report that microtubule stabiliza...

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Veröffentlicht in:	Cancer cell 2002-07, Vol.2 (1), p.43
Hauptverfasser:	O'Connor, Daniel S, Wall, Nathan R, Porter, Andrew C G, Altieri, Dario C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - analogs & derivatives Adenine - therapeutic use Animals Antineoplastic Agents, Phytogenic - pharmacology CDC2 Protein Kinase - metabolism Cell Cycle - drug effects Cell Survival - drug effects Dose-Response Relationship, Drug Enzyme Activation Female HeLa Cells Humans Inhibitor of Apoptosis Proteins Mice Mice, Knockout Mice, SCID Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Neoplasm Proteins Paclitaxel - pharmacology Phosphorylation Purines - pharmacology Spindle Apparatus - physiology Time Factors Tumor Cells, Cultured
Online-Zugang:	Volltext
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