Tumor cell-specific gene transfer with retroviral vectors displaying single-chain antibody

To specifically deliver the therapeutic gene to cancer cells and construct target retroviral vectors by inserting the single-chain variable antibody fragment into the retroviral envelope. Single-chain antibody expression vector pET -20bScfv was constructed. Binding activity of the genetically engine...

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Veröffentlicht in:	Chinese medical journal 2002-07, Vol.115 (7), p.1064
Hauptverfasser:	Tang, Yucheng, Li, Yu, Qian, Guanxiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Gene Transfer Techniques Genetic Therapy Genetic Vectors HeLa Cells Humans Immunoglobulin Fragments - genetics Neoplasms - therapy Retroviridae - genetics
Online-Zugang:	Volltext
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