Ca(2+) and Na(+) dependence of 3-hydroxyglutarate-induced excitotoxicity in primary neuronal cultures from chick embryo telencephalons

Glutaryl-CoA dehydrogenase deficiency (also known as glutaric aciduria type I) is an autosomal, recessively inherited neurometabolic disorder with a distinct neuropathology characterized by acute encephalopathy during a vulnerable period of brain development. Neuronal damage in this disease was demo...

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Veröffentlicht in:	Pediatric research 2002-08, Vol.52 (2), p.199
Hauptverfasser:	Kölker, Stefan, Köhr, Georg, Ahlemeyer, Barbara, Okun, Jürgen G, Pawlak, Verena, Hörster, Friederike, Mayatepek, Ertan, Krieglstein, Josef, Hoffmann, Georg F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - antagonists & inhibitors Adenosine Triphosphatases - metabolism Animals Calcium - metabolism Carrier Proteins Cations - metabolism Cells, Cultured Chick Embryo Electron Transport - drug effects Electron Transport Complex I Electron Transport Complex II Electron Transport Complex III - metabolism Electron Transport Complex IV - metabolism Glutarates - toxicity Homeostasis - drug effects Humans Kidney - cytology Membrane Proteins - antagonists & inhibitors Membrane Proteins - metabolism Multienzyme Complexes - metabolism NADH, NADPH Oxidoreductases - metabolism Neurons - drug effects Neurons - metabolism Neurotoxins - pharmacology Oxidoreductases - metabolism Receptors, AMPA - metabolism Receptors, N-Methyl-D-Aspartate - metabolism Recombinant Proteins - metabolism Sodium - metabolism Succinate Dehydrogenase - metabolism Telencephalon - cytology
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