$Treatment of Refractory Acute Leukemia with Timed Sequential Chemotherapy Using Topotecan Followed by Etoposide+Mitoxantrone (T-EM) and Correlation with Topoisomerase II Levels$

Treatment of Refractory Acute Leukemia with Timed Sequential Chemotherapy Using Topotecan Followed by Etoposide+Mitoxantrone (T-EM) and Correlation with Topoisomerase II Levels

A phase I/II clinical study evaluated 17 patients with refractory/recurrent acute leukemia treated with 1.5 mg/m 2 /day topotecan on days 1-3 followed by etoposide (100 mg/m 2 /day)+mitoxantrone (10 mg/m 2 /day) on days 4, 5 and 9, 10. Timed sequential chemotherapy using the topoisomerase I-inhibito...

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Veröffentlicht in:	Leukemia & lymphoma 2002, Vol.43 (5), p.989-999
Hauptverfasser:	Mainwaring, M.G., Rimsza, L.M., Chen, S.F., Gomez, S.P., Weeks, F.W., Reddy, V., Lynch, J., May, W.S., Kahn, S., Moreb, J., Leather, H., Braylan, R., Rowe, T.C., Finiewicz, K.J., Wingard, J.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adolescent Adult Aged Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use DNA Fragmentation DNA Topoisomerases, Type II - analysis DNA Topoisomerases, Type II - biosynthesis Enzyme Induction Etoposide - administration & dosage Female Humans Leukemia - drug therapy Leukemia - enzymology Male Middle Aged Mitoxantrone - administration & dosage Refractory Acute Leukemia Sequential Chemotherapy Topoisomerase Ii Topotecan Topotecan - administration & dosage
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