Evaluation of the influence of prostaglandin E2 on recombinant equine interleukin-1beta-stimulated matrix metalloproteinases 1, 3, and 13 and tissue inhibitor of matrix metalloproteinase 1 expression in equine chondrocyte cultures

To determine the effects of prostaglandin E2 (PGE2) on recombinant equine interleukin (IL)-1beta-stimulated expression of matrix metalloproteinases (MMP 1, MMP 3, MMP 13) and tissue inhibitor of matrix metalloproteinase 1 (TIMP 1) in vitro. Cultured equine chondrocytes. Stationary monolayers of firs...

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Veröffentlicht in:	American journal of veterinary research 2002-07, Vol.63 (7), p.987
Hauptverfasser:	Tung, Jayne T, Arnold, Carolyn E, Alexander, Lee H, Yuzbasiyan-Gurkan, Vilma, Venta, Patrick J, Richardson, Dean W, Caron, John P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Blotting, Northern - veterinary Chondrocytes - cytology Chondrocytes - drug effects Chondrocytes - enzymology Dinoprostone - pharmacology Drug Interactions Gene Expression Regulation, Enzymologic - drug effects Horses - metabolism Interleukin-1 - pharmacology Matrix Metalloproteinases - biosynthesis Matrix Metalloproteinases - genetics Phenylbutazone - pharmacology Recombinant Proteins - pharmacology Reverse Transcriptase Polymerase Chain Reaction - veterinary RNA - chemistry RNA - genetics Tissue Inhibitor of Metalloproteinase-1 - biosynthesis Tissue Inhibitor of Metalloproteinase-1 - genetics
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