DNA damage and biological effects induced by photosensitization with new N(1)-unsubstituted furo[2,3-h]quinolin-2(1H)-ones

New furoquinolinones unsubstituted at the N(1) position were prepared and their photobiological activities were studied in comparison with 4,6,8,9-tetramethylfuro[2,3-h]quinolin-2(1H)-one (HFQ) and 8-MOP. The anti-proliferative activity of furoquinolinones 3a-f was tested upon UVA irradiation in mam...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2002-09, Vol.10 (9), p.2835
Hauptverfasser:	Marzano, Cristina, Chilin, Adriana, Bordin, Franco, Baccichetti, Francarosa, Guiotto, Adriano
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteriophage T4 - drug effects Bacteriophage T4 - growth & development Bacteriophage T4 - radiation effects Cell Division - drug effects Cell Division - radiation effects Cell Survival - drug effects Cell Survival - radiation effects DNA - biosynthesis DNA - chemistry DNA - metabolism DNA Damage - drug effects DNA Damage - radiation effects Escherichia coli Guinea Pigs Humans Mice Mutagenesis - drug effects Mutagenesis - radiation effects Neoplasms, Experimental - pathology Photosensitivity Disorders - chemically induced Photosensitizing Agents - adverse effects Photosensitizing Agents - chemical synthesis Photosensitizing Agents - toxicity Quinolones - adverse effects Quinolones - chemical synthesis Quinolones - toxicity Structure-Activity Relationship Tumor Cells, Cultured Ultraviolet Rays
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