Effects of the Hallucinogen Psilocybin on Covert Orienting of Visual Attention in Humans
Hallucinogenic drug-induced states are considered as models for acute schizophrenic disorders (experimental psychoses). In a double-blind study with healthy volunteers we investigated the influence of the serotonergic hallucinogen psilocybin, the ecstasy-like drug 3,4-methylenedioxyethylamphetamine...
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| Veröffentlicht in: | Neuropsychobiology 2002-01, Vol.45 (4), p.205-212 |
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| container_title | Neuropsychobiology |
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| creator | Gouzoulis-Mayfrank, E. Thelen, B. Maier, S. Heekeren, K. Kovar, K.-A. Sass, H. Spitzer, M. |
| description | Hallucinogenic drug-induced states are considered as models for acute schizophrenic disorders (experimental psychoses). In a double-blind study with healthy volunteers we investigated the influence of the serotonergic hallucinogen psilocybin, the ecstasy-like drug 3,4-methylenedioxyethylamphetamine (MDE), the stimulant d- methamphetamine and placebo on covert orienting of spatial attention (n = 8 in each group). Reaction times were prolonged after ingestion of psilocybin > MDE, but not after d-methamphetamine. In addition, subjects on psilocybin exhibited particularly slow reaction times in invalid trials at short cue target intervals and failure of response inhibition in valid trials at long cue target intervals for right visual field targets. Despite some methodological limitations, these results are in line with both bilateral impairment of disengagement of attention and a lateralized impairment of inhibition of return (IOR) in productive psychotic states. Additional investigations with larger samples, different hallucinogenic substances (serotonergic agonists vs. NMDA antagonists) and different dose regimens are needed in order to further explore the suggested relationship between visuospatial attentional dysfunction and acute psychotic conditions. |
| doi_str_mv | 10.1159/000063672 |
| format | Article |
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Additional investigations with larger samples, different hallucinogenic substances (serotonergic agonists vs. NMDA antagonists) and different dose regimens are needed in order to further explore the suggested relationship between visuospatial attentional dysfunction and acute psychotic conditions.</description><identifier>ISSN: 0302-282X</identifier><identifier>EISSN: 1423-0224</identifier><identifier>DOI: 10.1159/000063672</identifier><identifier>PMID: 12097810</identifier><identifier>CODEN: NPBYAL</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>3,4-Methylenedioxyamphetamine - adverse effects ; 3,4-Methylenedioxyamphetamine - analogs & derivatives ; Activity levels. Psychomotricity ; Adult ; Attention - drug effects ; Biological and medical sciences ; Biological Psychology/Pharmacopsychology. Main Editor: P. Netter (Giessen) / Original Paper ; Central Nervous System Stimulants - adverse effects ; Double-Blind Method ; Female ; Fundamental and applied biological sciences. Psychology ; Hallucinogens - adverse effects ; Hallucinogens - pharmacology ; Humans ; Male ; Methamphetamine - adverse effects ; Middle Aged ; Psilocybin - adverse effects ; Psilocybin - pharmacology ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Reaction Time ; Space Perception - drug effects ; Vigilance. Attention. Sleep ; Visual Perception - drug effects</subject><ispartof>Neuropsychobiology, 2002-01, Vol.45 (4), p.205-212</ispartof><rights>2002 S. Karger AG, Basel</rights><rights>2002 INIST-CNRS</rights><rights>Copyright 2002 S. Karger AG, Basel</rights><rights>Copyright S. 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Additional investigations with larger samples, different hallucinogenic substances (serotonergic agonists vs. NMDA antagonists) and different dose regimens are needed in order to further explore the suggested relationship between visuospatial attentional dysfunction and acute psychotic conditions.</description><subject>3,4-Methylenedioxyamphetamine - adverse effects</subject><subject>3,4-Methylenedioxyamphetamine - analogs & derivatives</subject><subject>Activity levels. Psychomotricity</subject><subject>Adult</subject><subject>Attention - drug effects</subject><subject>Biological and medical sciences</subject><subject>Biological Psychology/Pharmacopsychology. Main Editor: P. Netter (Giessen) / Original Paper</subject><subject>Central Nervous System Stimulants - adverse effects</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hallucinogens - adverse effects</subject><subject>Hallucinogens - pharmacology</subject><subject>Humans</subject><subject>Male</subject><subject>Methamphetamine - adverse effects</subject><subject>Middle Aged</subject><subject>Psilocybin - adverse effects</subject><subject>Psilocybin - pharmacology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Reaction Time</subject><subject>Space Perception - drug effects</subject><subject>Vigilance. Attention. 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| ispartof | Neuropsychobiology, 2002-01, Vol.45 (4), p.205-212 |
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| subjects | 3,4-Methylenedioxyamphetamine - adverse effects 3,4-Methylenedioxyamphetamine - analogs & derivatives Activity levels. Psychomotricity Adult Attention - drug effects Biological and medical sciences Biological Psychology/Pharmacopsychology. Main Editor: P. Netter (Giessen) / Original Paper Central Nervous System Stimulants - adverse effects Double-Blind Method Female Fundamental and applied biological sciences. Psychology Hallucinogens - adverse effects Hallucinogens - pharmacology Humans Male Methamphetamine - adverse effects Middle Aged Psilocybin - adverse effects Psilocybin - pharmacology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Reaction Time Space Perception - drug effects Vigilance. Attention. Sleep Visual Perception - drug effects |
| title | Effects of the Hallucinogen Psilocybin on Covert Orienting of Visual Attention in Humans |
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