Bacterial lipopolysaccharide exposure alters aflatoxin B(1) hepatotoxicity: benchmark dose analysis for markers of liver injury

Aflatoxin B(1) (AFB(1)) is a fungal toxin that causes both acute hepatotoxicity and hepatocellular carcinoma in humans and experimental animals. Previous studies demonstrated that a small, noninjurious dose of bacterial lipopolysaccharide (LPS) augments the hepatotoxicity of AFB(1) through activatio...

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Veröffentlicht in:	Toxicological sciences 2002-07, Vol.68 (1), p.220
Hauptverfasser:	Luyendyk, James P, Shores, Kate C, Ganey, Patricia E, Roth, Robert A
Format:	Artikel
Sprache:	eng
Schlagworte:	Aflatoxin B1 - administration & dosage Aflatoxin B1 - toxicity Alanine Transaminase - blood Alkaline Phosphatase - blood Animals Aspartate Aminotransferases - blood Benchmarking Bile Ducts, Intrahepatic - drug effects Bile Ducts, Intrahepatic - pathology Chemical and Drug Induced Liver Injury - blood Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - pathology Cholestasis - chemically induced Cholestasis - pathology Dose-Response Relationship, Drug Drug Synergism Escherichia coli - immunology Injections, Intraperitoneal Lipopolysaccharides - pharmacology Liver - drug effects Liver - pathology Male No-Observed-Adverse-Effect Level Rats Rats, Sprague-Dawley
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