Enhancement of G-CSF-induced stem cell mobilization by antibodies against the beta 2 integrins LFA-1 and Mac-1

The beta 2 integrins leukocyte function antigen-1 (LFA-1, CD11a) and macrophage antigen-1 (Mac-1, CD11b) have been reported to play a role in the attachment of CD34(+) cells to stromal cells in the bone marrow. When administered prior to interleukin-8 (IL-8), anti-LFA-1 antibodies completely prevent...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Blood 2002-07, Vol.100 (1), p.327
Hauptverfasser:	Velders, Gerjo A, Pruijt, Johannes F M, Verzaal, Perry, van Os, Ronald, van Kooyk, Yvette, Figdor, Carl G, de Kruijf, Evert-Jan F M, Willemze, Roel, Fibbe, Willem E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - pharmacokinetics Antibodies, Monoclonal - pharmacology Blood Cells - cytology Blood Cells - drug effects Bone Marrow Cells - cytology Bone Marrow Cells - drug effects CD18 Antigens - immunology Colony-Forming Units Assay Drug Synergism Granulocyte Colony-Stimulating Factor - pharmacology Hematopoietic Stem Cell Mobilization - methods Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - drug effects Lymphocyte Function-Associated Antigen-1 - immunology Macrophage-1 Antigen - immunology Male Mice Mice, Inbred BALB C Mice, Knockout
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!