Lack of promotion of estrogen-dependent mammary gland tumors in vivo by an isopropanolic Cimicifuga racemosa extract

Cimicifuga racemosa (CR) is widely used in the treatment of menopausal symptoms. Mechanistic studies suggest that unlike hormone-replacement therapy, CR does not stimulate estrogen-receptor positive breast cancer cells. To evaluate CR safety, we performed an in vivo investigation of a clinically tes...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2002-06, Vol.62 (12), p.3448-3452
Hauptverfasser:	FREUDENSTEIN, Johannes, DASENBROCK, Clemens, NISSLEIN, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Propanol - chemistry 9,10-Dimethyl-1,2-benzanthracene Animals Biological and medical sciences Body Weight - drug effects Carcinogens Cell Division - drug effects Cimicifuga Drug toxicity and drugs side effects treatment Estrogens - physiology Female Follicle Stimulating Hormone - blood Luteinizing Hormone - blood Mammary Neoplasms, Experimental - blood Mammary Neoplasms, Experimental - chemically induced Mammary Neoplasms, Experimental - pathology Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Neoplasms, Hormone-Dependent - blood Neoplasms, Hormone-Dependent - chemically induced Neoplasms, Hormone-Dependent - pathology Pharmacology. Drug treatments Plant Extracts - pharmacology Plant Extracts - toxicity Prolactin - blood Ranunculaceae - chemistry Rats Rats, Sprague-Dawley
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