Giant pituitary adenomas: clinical characteristics and surgical results
Although most pituitary neoplasms are benign, some grow rapidly, spreading to extrasellar tissues. Definition of these 'giant' pituitary adenomas (PAs) is not clear. In order to clarify this question, we studied all pituitary macroadenomas operated in our hospital during the last 20 years,...
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| Veröffentlicht in: | British journal of neurosurgery 2002, Vol.16 (2), p.133-139 |
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| container_title | British journal of neurosurgery |
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| creator | Garibi, J. Pomposo, I. Villar, G. Gaztambide, S. |
| description | Although most pituitary neoplasms are benign, some grow rapidly, spreading to extrasellar tissues. Definition of these 'giant' pituitary adenomas (PAs) is not clear. In order to clarify this question, we studied all pituitary macroadenomas operated in our hospital during the last 20 years, differentiating those with diameter S 3 cm ( n = 43) and attempting to identify their typical features and prognosis. The reason for consultation was local in 58.3% of giant PAs, hormonal in 22.9% and tumour recurrence in 16.7%. Surgery was performed via a trans-sphenoidal approach in 92.5% of cases and succeeded in completely removing the tumour in only 27% of cases. In conclusion, we found that giant PAs are not a special type but the extreme case in the gradient of invasiveness of tumours of adenohypophyseal origin. They are characterized by a higher frequency of neuro-ophthalmological symptoms and hormonal deficits, and poorer response to surgical treatment. |
| doi_str_mv | 10.1080/02688690220131723 |
| format | Article |
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Definition of these 'giant' pituitary adenomas (PAs) is not clear. In order to clarify this question, we studied all pituitary macroadenomas operated in our hospital during the last 20 years, differentiating those with diameter S 3 cm ( n = 43) and attempting to identify their typical features and prognosis. The reason for consultation was local in 58.3% of giant PAs, hormonal in 22.9% and tumour recurrence in 16.7%. Surgery was performed via a trans-sphenoidal approach in 92.5% of cases and succeeded in completely removing the tumour in only 27% of cases. In conclusion, we found that giant PAs are not a special type but the extreme case in the gradient of invasiveness of tumours of adenohypophyseal origin. They are characterized by a higher frequency of neuro-ophthalmological symptoms and hormonal deficits, and poorer response to surgical treatment.</description><identifier>ISSN: 0268-8697</identifier><identifier>EISSN: 1360-046X</identifier><identifier>DOI: 10.1080/02688690220131723</identifier><identifier>PMID: 12046731</identifier><language>eng</language><publisher>Abingdon: Informa UK Ltd</publisher><subject>Adenoma ; Adenoma - complications ; Adenoma - pathology ; Adenoma - surgery ; Adult ; Age Distribution ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Clinical outcomes ; Endocrinopathies ; Female ; Giant ; Humans ; Hypothalamus. Hypophysis. Epiphysis (diseases) ; Male ; Medical sciences ; Middle Aged ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Pituitary ; Pituitary gland ; Pituitary Neoplasms - complications ; Pituitary Neoplasms - pathology ; Pituitary Neoplasms - surgery ; Prognosis ; Results ; Retrospective Studies ; Sex Distribution ; Surgery ; Surgical ; Treatment Outcome ; Vision Disorders - etiology</subject><ispartof>British journal of neurosurgery, 2002, Vol.16 (2), p.133-139</ispartof><rights>2002 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2002</rights><rights>2002 INIST-CNRS</rights><rights>Copyright Carfax Publishing Company Apr 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c556t-152274d630614b2fdb8de7bc3f8c0b66282f2acad47c15a35d02b3e573d8f46d3</citedby><cites>FETCH-LOGICAL-c556t-152274d630614b2fdb8de7bc3f8c0b66282f2acad47c15a35d02b3e573d8f46d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/02688690220131723$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/02688690220131723$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,776,780,4010,27900,27901,27902,59620,59726,60409,60515,61194,61229,61375,61410</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13665265$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12046731$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Garibi, J.</creatorcontrib><creatorcontrib>Pomposo, I.</creatorcontrib><creatorcontrib>Villar, G.</creatorcontrib><creatorcontrib>Gaztambide, S.</creatorcontrib><title>Giant pituitary adenomas: clinical characteristics and surgical results</title><title>British journal of neurosurgery</title><addtitle>Br J Neurosurg</addtitle><description>Although most pituitary neoplasms are benign, some grow rapidly, spreading to extrasellar tissues. Definition of these 'giant' pituitary adenomas (PAs) is not clear. In order to clarify this question, we studied all pituitary macroadenomas operated in our hospital during the last 20 years, differentiating those with diameter S 3 cm ( n = 43) and attempting to identify their typical features and prognosis. The reason for consultation was local in 58.3% of giant PAs, hormonal in 22.9% and tumour recurrence in 16.7%. Surgery was performed via a trans-sphenoidal approach in 92.5% of cases and succeeded in completely removing the tumour in only 27% of cases. In conclusion, we found that giant PAs are not a special type but the extreme case in the gradient of invasiveness of tumours of adenohypophyseal origin. They are characterized by a higher frequency of neuro-ophthalmological symptoms and hormonal deficits, and poorer response to surgical treatment.</description><subject>Adenoma</subject><subject>Adenoma - complications</subject><subject>Adenoma - pathology</subject><subject>Adenoma - surgery</subject><subject>Adult</subject><subject>Age Distribution</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Clinical outcomes</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Giant</subject><subject>Humans</subject><subject>Hypothalamus. Hypophysis. Epiphysis (diseases)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Pituitary</subject><subject>Pituitary gland</subject><subject>Pituitary Neoplasms - complications</subject><subject>Pituitary Neoplasms - pathology</subject><subject>Pituitary Neoplasms - surgery</subject><subject>Prognosis</subject><subject>Results</subject><subject>Retrospective Studies</subject><subject>Sex Distribution</subject><subject>Surgery</subject><subject>Surgical</subject><subject>Treatment Outcome</subject><subject>Vision Disorders - etiology</subject><issn>0268-8697</issn><issn>1360-046X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U2LFDEQBuAgijuu_gAv0gjrrdfKd3T3IovOCgteFLw11UnayZLuHpM0sv_ejDMyqKinHOp5K6kKIU8pnFMw8BKYMka9AsaAcqoZv0dWlCtoQajP98lqV28r0CfkUc63AJRJ0A_JCWVVaE5XZL0OOJVmG8oSCqa7Bp2f5hHz68bGMAWLsbEbTGiLTyGXYHODk2vykr78KCafl1jyY_JgwJj9k8N5Sj69e_vx6rq9-bB-f_XmprVSqtJSyZgWTnFQVPRscL1xXveWD8ZCrxQzbGBo0QltqUQuHbCee6m5M4NQjp-SF_u-2zR_XXwu3Riy9THi5Ocld5pqI41U_4UMlNBciAqf_wZv5yVNdYhqpJBgpKyI7pFNc87JD902hbHuq6PQ7f6i--MvaubZofHSj94dE4flV3B2AJjrKoeEkw356LhSkqnd5Zd7F6ZhTiN-m1N0XcG7OKefIf6vd1z8Et94jGVjMfnjpH9PfwcFc7Vx</recordid><startdate>2002</startdate><enddate>2002</enddate><creator>Garibi, J.</creator><creator>Pomposo, I.</creator><creator>Villar, G.</creator><creator>Gaztambide, S.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>2002</creationdate><title>Giant pituitary adenomas: clinical characteristics and surgical results</title><author>Garibi, J. ; Pomposo, I. ; Villar, G. ; Gaztambide, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c556t-152274d630614b2fdb8de7bc3f8c0b66282f2acad47c15a35d02b3e573d8f46d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adenoma</topic><topic>Adenoma - complications</topic><topic>Adenoma - pathology</topic><topic>Adenoma - surgery</topic><topic>Adult</topic><topic>Age Distribution</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Clinical outcomes</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Giant</topic><topic>Humans</topic><topic>Hypothalamus. Hypophysis. Epiphysis (diseases)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>Pituitary</topic><topic>Pituitary gland</topic><topic>Pituitary Neoplasms - complications</topic><topic>Pituitary Neoplasms - pathology</topic><topic>Pituitary Neoplasms - surgery</topic><topic>Prognosis</topic><topic>Results</topic><topic>Retrospective Studies</topic><topic>Sex Distribution</topic><topic>Surgery</topic><topic>Surgical</topic><topic>Treatment Outcome</topic><topic>Vision Disorders - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Garibi, J.</creatorcontrib><creatorcontrib>Pomposo, I.</creatorcontrib><creatorcontrib>Villar, G.</creatorcontrib><creatorcontrib>Gaztambide, S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of neurosurgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garibi, J.</au><au>Pomposo, I.</au><au>Villar, G.</au><au>Gaztambide, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Giant pituitary adenomas: clinical characteristics and surgical results</atitle><jtitle>British journal of neurosurgery</jtitle><addtitle>Br J Neurosurg</addtitle><date>2002</date><risdate>2002</risdate><volume>16</volume><issue>2</issue><spage>133</spage><epage>139</epage><pages>133-139</pages><issn>0268-8697</issn><eissn>1360-046X</eissn><abstract>Although most pituitary neoplasms are benign, some grow rapidly, spreading to extrasellar tissues. Definition of these 'giant' pituitary adenomas (PAs) is not clear. In order to clarify this question, we studied all pituitary macroadenomas operated in our hospital during the last 20 years, differentiating those with diameter S 3 cm ( n = 43) and attempting to identify their typical features and prognosis. The reason for consultation was local in 58.3% of giant PAs, hormonal in 22.9% and tumour recurrence in 16.7%. Surgery was performed via a trans-sphenoidal approach in 92.5% of cases and succeeded in completely removing the tumour in only 27% of cases. In conclusion, we found that giant PAs are not a special type but the extreme case in the gradient of invasiveness of tumours of adenohypophyseal origin. They are characterized by a higher frequency of neuro-ophthalmological symptoms and hormonal deficits, and poorer response to surgical treatment.</abstract><cop>Abingdon</cop><pub>Informa UK Ltd</pub><pmid>12046731</pmid><doi>10.1080/02688690220131723</doi><tpages>7</tpages></addata></record> |
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| source | Taylor & Francis CRKN Medical; MEDLINE; Taylor & Francis E-Journals |
| subjects | Adenoma Adenoma - complications Adenoma - pathology Adenoma - surgery Adult Age Distribution Aged Aged, 80 and over Biological and medical sciences Clinical outcomes Endocrinopathies Female Giant Humans Hypothalamus. Hypophysis. Epiphysis (diseases) Male Medical sciences Middle Aged Non tumoral diseases. Target tissue resistance. Benign neoplasms Pituitary Pituitary gland Pituitary Neoplasms - complications Pituitary Neoplasms - pathology Pituitary Neoplasms - surgery Prognosis Results Retrospective Studies Sex Distribution Surgery Surgical Treatment Outcome Vision Disorders - etiology |
| title | Giant pituitary adenomas: clinical characteristics and surgical results |
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