T-cell depletion and graft survival induced by anti-human CD3 immunotoxins in human CD3epsilon transgenic mice

Anti-CD3 immunotoxins are broad-spectrum immunosuppressive agents in a wide range of organ transplantation animal models with potential use in eliciting antigen-specific tolerance. However, the anti-CD3 immunotoxins used in animal studies do not cross-react with human T cells, limiting extrapolation...

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Veröffentlicht in:	Transplantation 2002-05, Vol.73 (10), p.1658
Hauptverfasser:	Weetall, Marla, Digan, Mary Ellen, Hugo, Ronald, Mathew, Sheba, Hopf, Christine, Tart-Risher, Nicole, Zhang, Jin, Shi, Victor, Fu, Fumin, Hammond-McKibben, Denise, West, Susan, Brack, Richard, Brinkmann, Volker, Bergman, Reinhard, Neville, Jr, David, Lake, Philip
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - pharmacology CD3 Complex - genetics CD3 Complex - immunology Concanavalin A - pharmacology Diphtheria Toxin - pharmacology Graft Survival - immunology Heart Transplantation - immunology Humans Immunotoxins - pharmacology Lipopolysaccharides - pharmacology Lymphocyte Activation Lymphocyte Culture Test, Mixed Lymphocyte Depletion - methods Mice Mice, Transgenic Recombinant Fusion Proteins - pharmacology Skin Transplantation - immunology T-Lymphocytes - drug effects T-Lymphocytes - immunology
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