A Chronic Bile Duct and Intravenous Cannulation Model in Conscious Rabbits for Pharmacokinetic Studies

In the development of novel pharmaceutical compounds, pharmacokinetic parameters, such as the extent of biliary excretion, must be characterized. Pharmacokinetic studies in nonrodent species, typically dogs, are generally required for new drug approvals. However, in some cases, rabbits may be a more...

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