Troglitazone induces a cellular acidosis by inhibiting acid extrusion in cultured rat mesangial cells

Department of Molecular and Cellular Physiology and Department of Pathology, Louisiana State University Health Science Center, Shreveport, Louisiana 71130 We studied the effect of troglitazone on cellular acid-base balance and alanine formation in isolated rat mesangial cells. Mesangial cells were g...

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Veröffentlicht in:	American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2002-06, Vol.282 (6), p.1600-R1607
Hauptverfasser:	Welbourne, Tomas, Su, Gan, Coates, Greg, Routh, Robert, McCarthy, Kevin, Battarbee, Harold
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid-Base Equilibrium - drug effects Acid-Base Equilibrium - physiology Acids - metabolism Alanine - biosynthesis Animals Cells, Cultured Chromans - pharmacology Dose-Response Relationship, Drug Glomerular Mesangium - cytology Glomerular Mesangium - drug effects Glomerular Mesangium - metabolism Hydrogen-Ion Concentration - drug effects Hypoglycemic Agents - pharmacology Intracellular Fluid - metabolism Lactic Acid - metabolism Rats Rats, Sprague-Dawley Thiazoles - pharmacology Thiazolidinediones
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