Encapsulated plasmid DNA treatment for human papillomavirus 16-associated anal dysplasia: A Phase I study of ZYC101

High-grade dysplasia induced by high-risk types of human papillomavirus (HPV) precedes invasive cancer in anal squamous epithelium just as it does in the cervix. A therapeutic HPV vaccine strategy as a potential treatment for anal dysplasia was tested in a standard Phase I dose escalation trial. The...

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Veröffentlicht in:	Clinical cancer research 2002-05, Vol.8 (5), p.1028-1037
Hauptverfasser:	KLENCKE, Barbara, MATIJEVIC, Mark, JAY, Naomi, DA COSTA, Maria, PALEFSKY, Joel M, URBAN, Robert G, LATHEY, Janet L, HEDLEY, Mary Lynne, BERRY, Michael, THATCHER, Joe, WEINBERG, Vivian, WILSON, Jennifer, DARRAGH, Teresa
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Anus Neoplasms - drug therapy Anus Neoplasms - immunology Anus Neoplasms - virology Applied cell therapy and gene therapy Biological and medical sciences DNA, Viral - drug effects DNA, Viral - genetics DNA, Viral - metabolism Dose-Response Relationship, Drug Erythema - chemically induced Fatigue - chemically induced Female Fever - chemically induced Headache - chemically induced HLA-A2 Antigen - immunology Humans Male Medical sciences Microspheres Middle Aged Oncogene Proteins, Viral - genetics Oncogene Proteins, Viral - immunology Oncogene Proteins, Viral - therapeutic use Pain - chemically induced Papillomaviridae - genetics Papillomaviridae - growth & development Papillomaviridae - immunology Papillomavirus E7 Proteins Papillomavirus Infections - drug therapy Papillomavirus Infections - immunology Papillomavirus Infections - virology Peptide Fragments - genetics Peptide Fragments - immunology Peptide Fragments - therapeutic use Pharmacology. Drug treatments Plasmids - administration & dosage Plasmids - genetics Time Factors Transfusions. Complications. Transfusion reactions. Cell and gene therapy Treatment Outcome Tumor Virus Infections - diagnosis Tumor Virus Infections - drug therapy Tumor Virus Infections - immunology Vaccines, DNA - adverse effects Vaccines, DNA - immunology Vaccines, DNA - therapeutic use
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