Melphalan availability in hypoxia-inducible factor-1alpha+/+ and factor-1alpha-/- tumors is independent of tumor vessel density and correlates with melphalan erythrocyte transport

Many tumors are impervious to anticancer agents. Resistance due to lack of cytotoxic penetration into the tumor is often overlooked but can play a significant role in undermining therapy. Insufficient and irregular vascularization of tumors is a possible barrier to drug delivery, but there are other...

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Veröffentlicht in:	International journal of cancer 2002-06, Vol.99 (4), p.514
Hauptverfasser:	Wildiers, Hans, Guetens, Gunter, de Boeck, Gert, Landuyt, Willy, Verbeken, Eric, Highley, Martin, de Bruijn, Ernst A, van Oosterom, Allan T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD34 - metabolism Antineoplastic Agents, Alkylating - pharmacokinetics Biological Transport Disease Models, Animal Erythrocytes - metabolism Humans Hypoxia-Inducible Factor 1, alpha Subunit Linear Models Male Melphalan - pharmacokinetics Mice Transcription Factors - metabolism Tumor Cells, Cultured Up-Regulation
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