Early vascular permeability in murine experimental peritonitis is co-mediated by resident peritoneal macrophages and mast cells: crucial involvement of macrophage-derived cysteinyl-leukotrienes

The initial phase of zymosan-induced peritonitis involves an increase of vascular permeability (peak at 30 min) that is correlated with high levels of vasoactive eicosanoids, namely, prostaglandins (PGI2 and PGE2) of cyclooxygenase-1 origin (as estimated by RT-PCR) and cysteinyl-leukotrienes. Previo...

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Veröffentlicht in:	Inflammation 2002-04, Vol.26 (2), p.61
Hauptverfasser:	Kolaczkowska, Elzbieta, Shahzidi, Susan, Seljelid, Rolf, van Rooijen, Nico, Plytycz, Barbara
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Ketoprostaglandin F1 alpha - biosynthesis Animals Capillary Leak Syndrome - etiology Capillary Leak Syndrome - physiopathology Capillary Permeability - physiology Cyclooxygenase 1 Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors - pharmacology Cysteine - secretion Diterpenes Eicosanoids - biosynthesis Enzyme Induction - drug effects Ginkgolides Histamine Release Indoles - pharmacology Indomethacin - pharmacology Isoenzymes - biosynthesis Isoenzymes - genetics Lactones - pharmacology Leukotriene C4 - biosynthesis Leukotrienes - secretion Lipoxygenase Inhibitors - pharmacology Macrophages, Peritoneal - physiology Macrophages, Peritoneal - secretion Male Mast Cells - physiology Mast Cells - secretion Membrane Proteins Mice Mice, Inbred BALB C Mice, Mutant Strains Nitrobenzenes - pharmacology Peritonitis - chemically induced Peritonitis - complications Peritonitis - physiopathology Phospholipid Ethers - pharmacology Platelet Activating Factor - antagonists & inhibitors Prostaglandin-Endoperoxide Synthases - biosynthesis Prostaglandin-Endoperoxide Synthases - genetics Quinolines - pharmacology Sulfonamides - pharmacology Thioglycolates - toxicity Zymosan - toxicity
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