β-Catenin Stabilization Dysregulates Mesenchymal Cell Proliferation, Motility, and Invasiveness and Causes Aggressive Fibromatosis and Hyperplastic Cutaneous Wounds

Fibroproliferative processes are a group of disorders in which there is excessive proliferation of spindle (mesenchymal fibroblast-like) cells. They range from hypertrophic scars to neoplasms such as aggressive fibromatosis. Cells from these disorders share cytologic similarity with fibroblasts pres...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2002-05, Vol.99 (10), p.6973-6978
Hauptverfasser:	Cheon, Sophia S., Alexander Y. L. Cheah, Turley, Stefanie, Nadesan, Puviindran, Poon, Raymond, Clevers, Hans, Alman, Benjamin A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggressive fibromatosis Animals Antibodies beta Catenin Biological Sciences Catenins Cell Division Cell growth Cell Movement Cells Cells, Cultured Cytoskeletal Proteins - genetics Cytoskeletal Proteins - metabolism Cytoskeletal Proteins - physiology Embryos Fibroblasts Fibroblasts - cytology Fibromatosis, Aggressive - genetics Fibromatosis, Aggressive - metabolism Fibromatosis, Aggressive - pathology Gastrointestinal Neoplasms - genetics Gastrointestinal Neoplasms - metabolism Gastrointestinal Neoplasms - pathology Gene Expression Regulation Genes Genes, Reporter Intestinal Polyps Mesoderm - cytology Mice Mice, Nude Mice, Transgenic Neurology Skin - injuries Studies Trans-Activators Transcriptional Activation Transgenes Transgenic animals Tumors Wound Healing Wounds and Injuries - metabolism
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