Glioblastoma multiforme as a manifestation of Turcot syndrome
Turcot's syndrome, clinically characterized by the coincident occurrence of primary tumors of the colon and the central nervous system, can genetically be divided into two syndromes: familial adenomatous polyposis (FAP) and hereditary nonpolyposis colon carcinoma (HNPCC). In the present case, a...
Gespeichert in:
| Veröffentlicht in: | Nervenarzt 2002-02, Vol.73 (2), p.177 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | ger |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 2 |
| container_start_page | 177 |
| container_title | Nervenarzt |
| container_volume | 73 |
| creator | Grips, E Wentzensen, N Sutter, C Sedlaczek, O Gebert, J Weigel, R Schwartz, A von Knebel-Doeberitz, M Hennerici, M |
| description | Turcot's syndrome, clinically characterized by the coincident occurrence of primary tumors of the colon and the central nervous system, can genetically be divided into two syndromes: familial adenomatous polyposis (FAP) and hereditary nonpolyposis colon carcinoma (HNPCC). In the present case, a 60-year-old patient with glioblastoma multiforme and a history of hereditary malignomas is described as an example of a HNPCC-associated Turcot's syndrome. New molecular biological methods and results give deeper insight into clinical syndromes, and the better understanding improves diagnostics, therapy, and outcome estimations, even in rare diseases. In the present case, a new germinal mutation could be identified. |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed</sourceid><recordid>TN_cdi_pubmed_primary_11975096</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>11975096</sourcerecordid><originalsourceid>FETCH-pubmed_primary_119750963</originalsourceid><addsrcrecordid>eNqFjTkOgzAQAF0kCuT4QuQPIC3kAIpUUY4H0KMFbMmRzSKvXfD7pEjqVKORRpqFSAGKKisqOCZizfwCgLIEWIkkz-vyBPU5FZeHNdRZ5EAOpYs2GE3eKYksP46j0YoDBkOjJC2b6HsKkudx8OTUViw1Wla7Lzdif78112c2xc6poZ28cejn9vc7_A3eRPM15w</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Glioblastoma multiforme as a manifestation of Turcot syndrome</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Grips, E ; Wentzensen, N ; Sutter, C ; Sedlaczek, O ; Gebert, J ; Weigel, R ; Schwartz, A ; von Knebel-Doeberitz, M ; Hennerici, M</creator><creatorcontrib>Grips, E ; Wentzensen, N ; Sutter, C ; Sedlaczek, O ; Gebert, J ; Weigel, R ; Schwartz, A ; von Knebel-Doeberitz, M ; Hennerici, M</creatorcontrib><description>Turcot's syndrome, clinically characterized by the coincident occurrence of primary tumors of the colon and the central nervous system, can genetically be divided into two syndromes: familial adenomatous polyposis (FAP) and hereditary nonpolyposis colon carcinoma (HNPCC). In the present case, a 60-year-old patient with glioblastoma multiforme and a history of hereditary malignomas is described as an example of a HNPCC-associated Turcot's syndrome. New molecular biological methods and results give deeper insight into clinical syndromes, and the better understanding improves diagnostics, therapy, and outcome estimations, even in rare diseases. In the present case, a new germinal mutation could be identified.</description><identifier>ISSN: 0028-2804</identifier><identifier>PMID: 11975096</identifier><language>ger</language><publisher>Germany</publisher><subject>Adaptor Proteins, Signal Transducing ; Base Pair Mismatch ; Brain Neoplasms - diagnosis ; Brain Neoplasms - genetics ; Carrier Proteins ; Colorectal Neoplasms, Hereditary Nonpolyposis - diagnosis ; Colorectal Neoplasms, Hereditary Nonpolyposis - genetics ; Female ; Glioblastoma - diagnosis ; Glioblastoma - genetics ; Humans ; Microsatellite Repeats - genetics ; Middle Aged ; MutL Protein Homolog 1 ; Neoplasm Proteins - genetics ; Nuclear Proteins ; Pedigree ; Syndrome ; Temporal Lobe</subject><ispartof>Nervenarzt, 2002-02, Vol.73 (2), p.177</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11975096$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Grips, E</creatorcontrib><creatorcontrib>Wentzensen, N</creatorcontrib><creatorcontrib>Sutter, C</creatorcontrib><creatorcontrib>Sedlaczek, O</creatorcontrib><creatorcontrib>Gebert, J</creatorcontrib><creatorcontrib>Weigel, R</creatorcontrib><creatorcontrib>Schwartz, A</creatorcontrib><creatorcontrib>von Knebel-Doeberitz, M</creatorcontrib><creatorcontrib>Hennerici, M</creatorcontrib><title>Glioblastoma multiforme as a manifestation of Turcot syndrome</title><title>Nervenarzt</title><addtitle>Nervenarzt</addtitle><description>Turcot's syndrome, clinically characterized by the coincident occurrence of primary tumors of the colon and the central nervous system, can genetically be divided into two syndromes: familial adenomatous polyposis (FAP) and hereditary nonpolyposis colon carcinoma (HNPCC). In the present case, a 60-year-old patient with glioblastoma multiforme and a history of hereditary malignomas is described as an example of a HNPCC-associated Turcot's syndrome. New molecular biological methods and results give deeper insight into clinical syndromes, and the better understanding improves diagnostics, therapy, and outcome estimations, even in rare diseases. In the present case, a new germinal mutation could be identified.</description><subject>Adaptor Proteins, Signal Transducing</subject><subject>Base Pair Mismatch</subject><subject>Brain Neoplasms - diagnosis</subject><subject>Brain Neoplasms - genetics</subject><subject>Carrier Proteins</subject><subject>Colorectal Neoplasms, Hereditary Nonpolyposis - diagnosis</subject><subject>Colorectal Neoplasms, Hereditary Nonpolyposis - genetics</subject><subject>Female</subject><subject>Glioblastoma - diagnosis</subject><subject>Glioblastoma - genetics</subject><subject>Humans</subject><subject>Microsatellite Repeats - genetics</subject><subject>Middle Aged</subject><subject>MutL Protein Homolog 1</subject><subject>Neoplasm Proteins - genetics</subject><subject>Nuclear Proteins</subject><subject>Pedigree</subject><subject>Syndrome</subject><subject>Temporal Lobe</subject><issn>0028-2804</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFjTkOgzAQAF0kCuT4QuQPIC3kAIpUUY4H0KMFbMmRzSKvXfD7pEjqVKORRpqFSAGKKisqOCZizfwCgLIEWIkkz-vyBPU5FZeHNdRZ5EAOpYs2GE3eKYksP46j0YoDBkOjJC2b6HsKkudx8OTUViw1Wla7Lzdif78112c2xc6poZ28cejn9vc7_A3eRPM15w</recordid><startdate>200202</startdate><enddate>200202</enddate><creator>Grips, E</creator><creator>Wentzensen, N</creator><creator>Sutter, C</creator><creator>Sedlaczek, O</creator><creator>Gebert, J</creator><creator>Weigel, R</creator><creator>Schwartz, A</creator><creator>von Knebel-Doeberitz, M</creator><creator>Hennerici, M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>200202</creationdate><title>Glioblastoma multiforme as a manifestation of Turcot syndrome</title><author>Grips, E ; Wentzensen, N ; Sutter, C ; Sedlaczek, O ; Gebert, J ; Weigel, R ; Schwartz, A ; von Knebel-Doeberitz, M ; Hennerici, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_119750963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>ger</language><creationdate>2002</creationdate><topic>Adaptor Proteins, Signal Transducing</topic><topic>Base Pair Mismatch</topic><topic>Brain Neoplasms - diagnosis</topic><topic>Brain Neoplasms - genetics</topic><topic>Carrier Proteins</topic><topic>Colorectal Neoplasms, Hereditary Nonpolyposis - diagnosis</topic><topic>Colorectal Neoplasms, Hereditary Nonpolyposis - genetics</topic><topic>Female</topic><topic>Glioblastoma - diagnosis</topic><topic>Glioblastoma - genetics</topic><topic>Humans</topic><topic>Microsatellite Repeats - genetics</topic><topic>Middle Aged</topic><topic>MutL Protein Homolog 1</topic><topic>Neoplasm Proteins - genetics</topic><topic>Nuclear Proteins</topic><topic>Pedigree</topic><topic>Syndrome</topic><topic>Temporal Lobe</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grips, E</creatorcontrib><creatorcontrib>Wentzensen, N</creatorcontrib><creatorcontrib>Sutter, C</creatorcontrib><creatorcontrib>Sedlaczek, O</creatorcontrib><creatorcontrib>Gebert, J</creatorcontrib><creatorcontrib>Weigel, R</creatorcontrib><creatorcontrib>Schwartz, A</creatorcontrib><creatorcontrib>von Knebel-Doeberitz, M</creatorcontrib><creatorcontrib>Hennerici, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Nervenarzt</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grips, E</au><au>Wentzensen, N</au><au>Sutter, C</au><au>Sedlaczek, O</au><au>Gebert, J</au><au>Weigel, R</au><au>Schwartz, A</au><au>von Knebel-Doeberitz, M</au><au>Hennerici, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glioblastoma multiforme as a manifestation of Turcot syndrome</atitle><jtitle>Nervenarzt</jtitle><addtitle>Nervenarzt</addtitle><date>2002-02</date><risdate>2002</risdate><volume>73</volume><issue>2</issue><spage>177</spage><pages>177-</pages><issn>0028-2804</issn><abstract>Turcot's syndrome, clinically characterized by the coincident occurrence of primary tumors of the colon and the central nervous system, can genetically be divided into two syndromes: familial adenomatous polyposis (FAP) and hereditary nonpolyposis colon carcinoma (HNPCC). In the present case, a 60-year-old patient with glioblastoma multiforme and a history of hereditary malignomas is described as an example of a HNPCC-associated Turcot's syndrome. New molecular biological methods and results give deeper insight into clinical syndromes, and the better understanding improves diagnostics, therapy, and outcome estimations, even in rare diseases. In the present case, a new germinal mutation could be identified.</abstract><cop>Germany</cop><pmid>11975096</pmid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-2804 |
| ispartof | Nervenarzt, 2002-02, Vol.73 (2), p.177 |
| issn | 0028-2804 |
| language | ger |
| recordid | cdi_pubmed_primary_11975096 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Adaptor Proteins, Signal Transducing Base Pair Mismatch Brain Neoplasms - diagnosis Brain Neoplasms - genetics Carrier Proteins Colorectal Neoplasms, Hereditary Nonpolyposis - diagnosis Colorectal Neoplasms, Hereditary Nonpolyposis - genetics Female Glioblastoma - diagnosis Glioblastoma - genetics Humans Microsatellite Repeats - genetics Middle Aged MutL Protein Homolog 1 Neoplasm Proteins - genetics Nuclear Proteins Pedigree Syndrome Temporal Lobe |
| title | Glioblastoma multiforme as a manifestation of Turcot syndrome |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T19%3A19%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Glioblastoma%20multiforme%20as%20a%20manifestation%20of%20Turcot%20syndrome&rft.jtitle=Nervenarzt&rft.au=Grips,%20E&rft.date=2002-02&rft.volume=73&rft.issue=2&rft.spage=177&rft.pages=177-&rft.issn=0028-2804&rft_id=info:doi/&rft_dat=%3Cpubmed%3E11975096%3C/pubmed%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/11975096&rfr_iscdi=true |