A novel peptide derivative exhibits anti inflammatory and antioxidant activity in adjuvant induced arthritis in rats

A tetrapeptide derivative PEP1261 [Boc-Lys-(Boc)-Arg-Asp-Ser-(tBu)-OtBu], corresponding to residues 39-42 of human lactoferrin, was tested for its antiinflammatory action in adjuvant induced arthritis in rats. Administration of heat killed Mycobacterium tuberculosis (500 microg/0.1 ml of paraffin oi...

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Veröffentlicht in:	Molecular and cellular biochemistry 2002-01, Vol.229 (1-2), p.9
Hauptverfasser:	Kumar, Dilly Ashok, Manikandan, Panchatcharam, Sumitra, Miriyala, Raju, Kalidindi V S Narayana, Gayathri, Chandrasekar, Arutselvan, Natarajan, Puvanakrishnan, Rengarajulu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - metabolism Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Antioxidants - metabolism Antioxidants - therapeutic use Arthritis, Experimental - drug therapy Bone and Bones - metabolism Diclofenac - metabolism Diclofenac - pharmacology Glucuronidase - metabolism Lactoferrin - therapeutic use Lysosomes - metabolism Male Peptide Fragments - therapeutic use Rats Rats, Wistar Reactive Oxygen Species - metabolism
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