Factor V Activation and Inactivation by Venom Proteases

Blood coagulation factor V is a single-chain glycoprotein with M r = 330,000 which plays an important role in the procoagulant and anticoagulant pathways. Thrombin activates factor V into factor Va, a two-chain molecule which is composed of a heavy (M r = 105,000) and a light chain (M r = 71,000/74,...

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Veröffentlicht in:	Haemostasis 2001-05, Vol.31 (3-6), p.241-246
Hauptverfasser:	Rosing, Jan, Govers-Riemslag, José W.P., Yukelson, Lev, Tans, Guido
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Endopeptidases - chemistry Endopeptidases - pharmacology Factor V - drug effects Factor V - metabolism Factor Va - drug effects Factor Va - metabolism Humans Procoagulant Proteins and Diagnostic Agents Snake Venoms - chemistry Snake Venoms - enzymology Snake Venoms - pharmacology Venoms - chemistry Venoms - pharmacology
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