Rac Activation Induces NADPH Oxidase Activity in Transgenic COSphox Cells, and the Level of Superoxide Production Is Exchange Factor-dependent

Transient expression of constitutively active Rac1 derivatives, (G12V) or (Q61L), was sufficient to induce phagocyte NADPH oxidase activity in a COS-7 cell model in which human cDNAs for essential oxidase components, gp91phox, p22phox, p47phox, and p67phox, were expressed as stable transgenes. Expre...

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Veröffentlicht in:	The Journal of biological chemistry 2002-05, Vol.277 (21), p.19220-19228
Hauptverfasser:	Price, Marianne O., Atkinson, Simon J., Knaus, Ulla G., Dinauer, Mary C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified COS Cells Enzyme Induction Fluorescent Antibody Technique Humans Microscopy, Confocal NADPH Oxidases - biosynthesis NADPH Oxidases - genetics Phagocytes - enzymology Protein Transport rac1 GTP-Binding Protein - metabolism Signal Transduction Superoxides - metabolism
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