Polymorphisms in Genes Encoding Drugs and Xenobiotic Metabolizing Enzymes, DNA Repair Enzymes, and Response to Treatment of Childhood Acute Lymphoblastic Leukemia

Purpose : The most common childhood malignancy, acute lymphoblastic leukemia (ALL), remains the leading cause of cancer-related death in children because of resistant cases in which underlying predisposing factors are poorly understood. The interindividual variation in the activity of xenobiotic met...

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Veröffentlicht in:	Clinical cancer research 2002-03, Vol.8 (3), p.802-810
Hauptverfasser:	KRAJINOVIC, Maja, LABUDA, Damian, MATHONNET, Geraldine, LABUDA, Marcin, MOGHRABI, Albert, CHAMPAGNE, Josette, SINNETT, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyltransferases - genetics Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Child Child, Preschool Cytochrome P-450 Enzyme System - genetics Disease Susceptibility DNA Repair - genetics Genotype Glutathione Transferase - genetics Hematologic and hematopoietic diseases Humans Infant Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences NAD(P)H Dehydrogenase (Quinone) - genetics Polymorphism, Genetic Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor Cell Lymphoblastic Leukemia-Lymphoma - enzymology Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality Prognosis Survival Rate Treatment Outcome Xenobiotics - metabolism
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